張勁松
性別：男
單位：茶與食品科技學(xué)院
研究方向：營養(yǎng)與毒理；茶與健康
技術(shù)職務(wù)：教授
E-mail：zjs@ahau.edu.cn
通訊地址：合肥市長江西路130號
郵政編碼：230036

工作經(jīng)歷
2009．3至今 安徽農(nóng)業(yè)大學(xué) 茶與食品科技學(xué)院
2002．3─2009．2 中國科學(xué)技術(shù)大學(xué) 化學(xué)與材料科學(xué)學(xué)院
2000．3─2002．2 Institute of Food Research，Norwich，UK
1999．8─2000．2 中國科學(xué)技術(shù)大學(xué) 化學(xué)與材料科學(xué)學(xué)院
1988．9─1999．7 國家煙草專賣局 合肥經(jīng)濟(jì)技術(shù)學(xué)院

學(xué)習(xí)經(jīng)歷
2002．9─2004．7 中國科學(xué)院 固體物理研究所 博士
1985．9─1988．7 安徽農(nóng)學(xué)院 茶業(yè)系 碩士
1981．9─1985．7 安徽農(nóng)學(xué)院 茶業(yè)系 學(xué)士

榮譽(yù)
全國優(yōu)秀教師
第三屆中國優(yōu)秀青年科技創(chuàng)業(yè)獎(jiǎng)

研究興趣
茶與健康、茶與硒生物效應(yīng)相互影響<3，4>（23，26，28），硒研究涉及硒毒性、藥效、營養(yǎng)和酶靶。
硒毒性：發(fā)明納米硒（ZL97107038．5）并闡述其高安全性（1，2，4-6，9，13，20，24，26），基于納米硒低毒特征，F(xiàn)DA毒理學(xué)研究中心前任主任邀請參編兩部毒理學(xué)專著<1，2>，納米硒為衛(wèi)生部批準(zhǔn)的保健食品，屬國家級新產(chǎn)品。
硒藥效：發(fā)明硒代硫酸鈉與一線化療藥順鉑聯(lián)用治療腫瘤（ZL200710023256．4），在肝癌模型上，順鉑至多取得25%治愈率，聯(lián)用至少產(chǎn)生75%治愈率（8，15，19，25），Cancer Weekly三次報(bào)道該項(xiàng)研究進(jìn)展。
硒營養(yǎng)：發(fā)現(xiàn)硒與西蘭花中萊菔硫烷協(xié)同誘導(dǎo)硫氧還蛋白還原酶，硒與西蘭花可能是防癌伴侶（3），BBC News，The Times，The Guardian，Genomics and Genetics Weekly，Cancer Weekly等報(bào)道此發(fā)現(xiàn)。
硒酶靶：基于動(dòng)物實(shí)驗(yàn)，說明硫氧還蛋白還原酶是抗癌藥的藥靶和毒靶（7，11，12，17，18，21，27），美國Threshold Pharmaceuticals公司邀請?jiān)u價(jià)抗癌新藥TH-302藥理，發(fā)現(xiàn)它抑制該酶活力（22）。

專著章節(jié)
<4> Zhang L, Wu S, Wang D, Wan X, Zhang J*. Epigallocatechin-3-gallate (EGCG) in or on nanoparticles: Enhanced stability and bioavailability of EGCG encapsulated in nanoparticles or targeted delivery of gold nanoparticles coated with EGCG. In: Casciano D, Sahu SC (eds) Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology. John Wiley & Sons. Invited chapter in preparation. (* communication author)
<3> Zhang L, Zhang Z, Lu Y, Zhang J, Preedy VR. L-theanine from green tea: Transport and effects on health. In: Preedy VR (ed) Tea in Health and Disease Prevention. Academic Press. pp 425-435, 2012.
<2> Zhang J*, Spallholz J. Toxicity of selenium compounds and nano-selenium particles. In: Casciano D, Sahu SC (eds) Handbook of Systems Toxicology. John Wiley & Sons. pp 787-802, 2011.
<1> Zhang J*. Biological properties of red elemental selenium at nano size (Nano-Se) in vitro and in vivo. In: Sahu SC, Casciano D (eds) Nanotoxicity: From In Vivo and In Vitro Model to Health Risks. John Wiley & Sons. pp 97-114, 2009.

論文和論文評審
第一或通訊作者25篇，第二作者3篇，篇均影響因子4.2，他引超過500次（Web of Science）。Chemical Reviews、Journal of the American Chemical Society、Biomaterials等15種SCI期刊21次邀請論文評審。
（28）Sun K, Wu S, Wang Y, Wan X, Thompson HJ, Zhang J*. High-dose sodium selenite toxicity cannot be prevented by the co-administration of pharmacological levels of epigallocatechin-3-gallate which in turn aggravates the toxicity. Food Chem. Toxicol. 52:36–41, 2013.
（27）Wang Y, Lu H, Wang D, Li S, Sun K, Wan X, Taylor EW, Zhang J*. Inhibition of glutathione synthesis eliminates the adaptive response of ascitic hepatoma 22 cells to nedaplatin that targets thioredoxin reductase. Toxicol. Appl. Pharmacol. 265:342-350, 2012.
（26）Wang D, Taylor EW, Wang Y, Wan X, Zhang J*. Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention. Int. J. Nanomedicine 7:1711–1721, 2012.
（25）Li J, Sun K, Ni L, Wang X, Wang D, Zhang J*. Sodium selenosulfate at an innocuous dose markedly prevents cisplatin-induced gastrointestinal toxicity. Toxicol. Appl. Pharmacol. 258:376-383, 2012.
（24）Zhang J*, Taylor EW, Wan X, Peng D*. Impact of heat treatment on size, structure, and bioactivity of elemental selenium nanoparticles. Int. J. Nanomedicine 7:815–825, 2012.
（23）Lu Y, Zhang J, Wan X, Long M, Li D, Lei P, Zhang Z. Intestinal transport of pure theanine and theanine in green tea extract: Green tea components inhibit theanine absorption and promote theanine excretion. Food Chem. 125:277-280, 2011.
（22）Li S, Zhang J*, Li J, Chen D, Matteucci M, Curd J, Duan J. Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302. Biol. Trace Elem. Res. 136:294-301, 2010.
（21）Wang X, Zhang J*, Xu T. Cyclophosphamide-evoked heart failure involves pronounced co-suppression of cytoplasmic thioredoxin reductase activity and non-protein free thiol level. Eur. J. Heart Failure 11:154-162, 2009.
（20）Zhang J*, Wang X, Xu T. Elemental selenium at nano size(Nano-Se)as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with se-methylselenocysteine in mice. Toxicol. Sci. 101:22-31, 2008.
（19）Zhang J*,Peng D, Lu H, Liu Q. Attenuating the toxicity of cisplatin by using selenosulfate with reduced risk of selenium toxicity as compared with selenite. Toxicol. Appl. Pharmacol. 226:251-259, 2008.
（18）Zhang J*, Wang X, Lu H. Amifostine increases cure rate of cisplatin on ascites hepatoma 22 via selectively protecting renal thioredoxin reductase. Cancer Lett. 260:127-136, 2008.
（17）Wang X, Zhang J*, Xu T. Thioredoxin reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy. Eur. J. Pharmacol. 579:66-73, 2008.
（16）Zhang J*, Wang H, Peng D, Taylor EW. Further insight into the impact of sodium selenite on selenoenzymes: High-dose selenite enhances hepatic thioredoxin reductase 1 activity as a consequence of liver injury. Toxicol. Lett. 176:223-229, 2008.
（15）Zhang J*, Lu H, Wang X. Sodium selenosulfate synthesis and demonstration of its in vitro cytotoxic activity against HepG2, Caco2 and three kinds of leukemia cells. Biol. Trace Elem. Res. 125:13-21, 2008.
（14）Li H, Zhang J, Wang T, Luo W, Zhou Q, Jiang G. Elemental selenium particles at nano size(Nano-Se)are more toxic to Medaka(Oryzias latipes)as a consequence of hyper-accumulation of selenium: A comparison with sodium selenite. Aquat. Toxicol. 89:251-256, 2008.
（13）Wang H, Zhang J*, Yu H. Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice. Free Radic. Biol. Med. 42:1524-1533, 2007.
（12）Zhang J*, Lu H. Ifosfamide induces acute renal failure via inhibition of the thioredoxin reductase activity. Free Radic. Biol. Med. 43:1574-1583, 2007.
（11）Wang X, Zhang J*, Xu T. Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo. Toxicol. Appl. Pharmacol. 218:88-95, 2007.
（10）Zhang J*, Wang H, Yu H. Thioacetamide-induced cirrhosis in selenium-adequate mice displays rapid and persistent abnormity of hepatic selenoenzymes which are mute to selenium supplementation. Toxicol. Appl. Pharmacol. 224:81-88, 2007.
（9）Peng D, Zhang J*, Liu Q, Taylor EW. Size effect of elemental selenium nanoparticles(Nano-Se)at supranutritional levels on selenium accumulation and glutathione S-transferase activity. J. Inorg. Biochem. 101:1457-1463, 2007.
（8）Peng D, Zhang J*, Liu Q. Effect of sodium selenosulfate on restoring activities of selenium-dependent enzymes and selenium retention compared with sodium selenite in vitro and in vivo. Biol. Trace Elem. Res. 117:77-88, 2007.
（7）Zhang J*, Ma K, Wang H. Cyclophosphamide suppresses thioredoxin reductase in bladder tissue and its adaptive response via inductions of thioredoxin reductase and glutathione peroxidase. Chem Biol. Interact. 162:24-30, 2006.
（6）Zhang J*, Wang H, Yan X, Zhang L. Comparison of short-term toxicity between Nano-Se and selenite in mice. Life Sci. 76:1099-1109, 2005.
（5）Zhang J*, Wang H, BaoY, Zhang L. Nano red elemental selenium has no size effect in the induction of seleno-enzymes in both cultured cells and mice. Life Sci. 75:237-244, 2004.
（4）Huang B#, Zhang J#, Hou J, Chen C. Free radical scavenging efficiency of Nano-Se in vitro. Free Radic. Biol. Med. 35:805-813, 2003.(# contributed equally)
（3）Zhang J, Svehlíková V, Bao Y, Howie AF, Beckett GJ, Williamson G. Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis 24:497-503, 2003.
（2）Gao X, Zhang J, Zhang L. Hollow sphere selenium nanoparticles: their in-vitro anti hydroxyl radical effect. Adv. Mater. 14:290-293, 2002.
（1）Zhang J, Gao X, Zhang L, Bao Y. Biological effects of a nano red elemental selenium. Biofactors 15:27-38, 2001.

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