大連理工大學(xué)導(dǎo)師：丁凡舒 正文

[導(dǎo)師姓名]
丁凡舒

[所屬院校]
大連理工大學(xué)

[基本信息]
導(dǎo)師姓名：丁凡舒
性別：女
人氣指數(shù)：940
所屬院校：大連理工大學(xué)
所屬院系：
職稱：
導(dǎo)師類型：碩導(dǎo)
招生專業(yè)：

[通訊方式]
電子郵件：dingfs@dlut.edu.cn

[個(gè)人簡(jiǎn)述]
竇同意，男，1987年1月出生，山東濟(jì)寧人。
主要學(xué)歷及工作經(jīng)歷:
2005.09—2009.07天津大學(xué)制藥工程工學(xué)學(xué)士
2009.09—2016.01中科院大連化物所生物化工工學(xué)博士
2015.03—2015.06芬蘭赫爾辛基大學(xué)分子藥理博士交流生
2015.03—2015.06大連理工大學(xué)生命與醫(yī)藥學(xué)院講師
主要研究領(lǐng)域：
1.生物大數(shù)據(jù)分析與數(shù)據(jù)挖掘（生物信息學(xué)）；
2.蛋白質(zhì)結(jié)構(gòu)功能關(guān)系研究（生物化學(xué)與分子生物學(xué)）。
承擔(dān)項(xiàng)目：
1.大連理工大學(xué)基本科研業(yè)務(wù)費(fèi)DUT16RC(3)016
Xyl_S酶的催化機(jī)理及其關(guān)鍵催化結(jié)構(gòu)域的鑒定2016.4-2017.12
2.國(guó)家自然科學(xué)基金-青年基金24萬(wàn)
一種新型去糖基酶的催化機(jī)理及其關(guān)鍵催化結(jié)構(gòu)域的鑒定316006412017.1-2019.12
代表性論文：
[1]TongyiDou,HongweiLuan,GuangboGe,MingmingDong,HanfaZou,YuqiHe,PanCui,JiayueWang,DachengHao,ShilinYang,LingYang*."Functionalandstructuralpropertiesofanovelcellulosome-likemultienzymecomplex:efficientglycosidehydrolysisofwater-insoluble7-xylosyl-10-deacetylpaclitaxel."ScientificReports,5,13768.（SCI,IF:5.578）
[2]TongyiDou,HongweiLuan,XingbaoLiu,ShiyangLi,XunfuDuandLingYang*."Enzymatichydrolysisof7-xylosyltaxanesbyanextracellularxylosidasefromCellulosimicrobiumcellulans."BiotechnologyLetters,2015,37(9):1905-1910.（SCI,IF:1.591）
[3]ZiruDai,GuangboGe,LeiFeng,JingNing,LianghaiHu,QiangJin,DandanWang,XiaLv,TongyiDou,JingnanCui,LingYang*."Ahighlyselectiveratiometrictwo-photonfluorescentprobeforhumancytochromeP4501A."JournaloftheAmericanChemicalSociety,2015,137(45):14488-95.（SCI,IF:12.113）
[4]Xing-KaiQian,PingWang,Yang-LiuXia,TongyiDou,QiangJin,Dan-DanWang,Da-ChengHao,Xiao-LinBi,Guang-BoGe,LingYang,Ahighlyselectivefluorescentprobeforsensingactivitiesofcatechol-O-methyltransferaseincomplexbiologicalsamples.SensorsandActuatorsB:Chemical,2016,231:615–623
[5]錢星凱，夏楊柳，竇同意，侯潔，馬紅，葛廣波，秘曉林，楊凌*.兒茶酚-氧位-甲基轉(zhuǎn)移酶與疾病的關(guān)系,《藥學(xué)學(xué)報(bào)》，2016,51(4):543-551.（綜合影響因子1.201，復(fù)合影響因子1.684，主辦方：中國(guó)藥學(xué)會(huì)）
[6]PanCui,TongyiDou(并列第一),GuangboGe.EfficientenzymaticpreparationofEsculentosideBfollowingconditionoptimizationbyresponsesurfacemethodology.JournalofMolecularCatalysisB:Enzymatic,Accepted.（SCI,IF:2.128）
[7]PanCui,TongyiDou(并列第一),GuangboGe.Highlyselectiveandefficientbiotransformationoflinarintoproducetilianinbynaringinase.BiotechnologyLetters,2016,38:1367–1373.（SCI,IF:1.591）
[8]YangliuXia,XiaLv,GuiyuanHe,TongyiDou,Guang-BoGe,LingYang.InvitrocharacterizationoftheglucuronidationpathwaysofD-luciferinmediatedbyhumanUDP-glucuronosyltransferases.DrugMetabolismandPharmacokinetics,2017,32(1):S77
[9]WeiLei,Dan-DanWang,TongyiDou,JieHou,LiangFeng,HengYin,QunLuo,JieSun,Guang-BoGe,LingYang.Assessmentoftheinhibitoryeffectsofpyrethroidsagainsthumancarboxylesterases.ToxicologyandAppliedPharmacology,2017,321:48–56
[10]Zi-MiaoWeng,PingWang,Guang-BoGe,Zi-RuDai,Da-ChangWu,Li-WeiZou,TongyiDou,JieHou,Tong-YanZhang,LingYang.Structure-activityrelationshipsofflavonoidsasnaturalinhibitorsagainstE.coliβ-glucuronidase.FoodandChemicalToxicology,Availableonline24March2017,https://doi.org/10.1016/j.fct.2017.03.042
[11]Jing-JingWu,Yun-FengCao,LiangFeng,Yu-QiHe,JamesY.Hong,TongyiDou,PingWang,Da-ChengHao,Guang-BoGe,andLingYang.ANaturallyOccurringIsoform-SpecificProbeforHighlySelectiveandSensitiveDetectionofHumanCytochromeP4503A5,J.Med.Chem.,2017,60(9):3804–3813
[12]PingWang,Yang-LiuXia,Li-WeiZou,Xing-KaiQian,TongyiDou,QiangJin,Shi-YangLi,YangYu,Dan-DanWang,QunLuo,GuangboGe,LingYang.AnOptimizedTwo-PhotonFluorescentProbeforBiologicalSensingandImagingofCatechol-O-Methyltransferase.Chemistry,2017,23(45):10800-10807.
[13]Li-WeiZou,TongyiDou(并列第一),PingWang,WeiLei,Zi-MiaoWeng,JieHou,Dan-DanWang,Yi-MingFan,Wei-DongZhang,Guang-BoGe,LingYang,Structure-activityrelationshipsofpentacyclictriterpenoidsaspotentandselectiveinhibitorsagainsthumancarboxylesterase1,FrontiersinPharmacology,2017,8:435.

[科研工作]
主要研究領(lǐng)域：
1.生物大數(shù)據(jù)分析與數(shù)據(jù)挖掘（生物信息學(xué)）；
2.蛋白質(zhì)結(jié)構(gòu)功能關(guān)系研究（生物化學(xué)與分子生物學(xué)）。
承擔(dān)項(xiàng)目：
1.大連理工大學(xué)基本科研業(yè)務(wù)費(fèi)DUT16RC(3)016
Xyl_S酶的催化機(jī)理及其關(guān)鍵催化結(jié)構(gòu)域的鑒定2016.4-2017.12
2.國(guó)家自然科學(xué)基金-青年基金24萬(wàn)
一種新型去糖基酶的催化機(jī)理及其關(guān)鍵催化結(jié)構(gòu)域的鑒定316006412017.1-2019.12
代表性論文：
[1]TongyiDou,HongweiLuan,GuangboGe,MingmingDong,HanfaZou,YuqiHe,PanCui,JiayueWang,DachengHao,ShilinYang,LingYang*."Functionalandstructuralpropertiesofanovelcellulosome-likemultienzymecomplex:efficientglycosidehydrolysisofwater-insoluble7-xylosyl-10-deacetylpaclitaxel."ScientificReports,5,13768.（SCI,IF:5.578）
[2]TongyiDou,HongweiLuan,XingbaoLiu,ShiyangLi,XunfuDuandLingYang*."Enzymatichydrolysisof7-xylosyltaxanesbyanextracellularxylosidasefromCellulosimicrobiumcellulans."BiotechnologyLetters,2015,37(9):1905-1910.（SCI,IF:1.591）
[3]ZiruDai,GuangboGe,LeiFeng,JingNing,LianghaiHu,QiangJin,DandanWang,XiaLv,TongyiDou,JingnanCui,LingYang*."Ahighlyselectiveratiometrictwo-photonfluorescentprobeforhumancytochromeP4501A."JournaloftheAmericanChemicalSociety,2015,137(45):14488-95.（SCI,IF:12.113）
[4]Xing-KaiQian,PingWang,Yang-LiuXia,TongyiDou,QiangJin,Dan-DanWang,Da-ChengHao,Xiao-LinBi,Guang-BoGe,LingYang,Ahighlyselectivefluorescentprobeforsensingactivitiesofcatechol-O-methyltransferaseincomplexbiologicalsamples.SensorsandActuatorsB:Chemical,2016,231:615–623
[5]錢星凱，夏楊柳，竇同意，侯潔，馬紅，葛廣波，秘曉林，楊凌*.兒茶酚-氧位-甲基轉(zhuǎn)移酶與疾病的關(guān)系,《藥學(xué)學(xué)報(bào)》，2016,51(4):543-551.（綜合影響因子1.201，復(fù)合影響因子1.684，主辦方：中國(guó)藥學(xué)會(huì)）
[6]PanCui,TongyiDou(并列第一),GuangboGe.EfficientenzymaticpreparationofEsculentosideBfollowingconditionoptimizationbyresponsesurfacemethodology.JournalofMolecularCatalysisB:Enzymatic,Accepted.（SCI,IF:2.128）
[7]PanCui,TongyiDou(并列第一),GuangboGe.Highlyselectiveandefficientbiotransformationoflinarintoproducetilianinbynaringinase.BiotechnologyLetters,2016,38:1367–1373.（SCI,IF:1.591）
[8]YangliuXia,XiaLv,GuiyuanHe,TongyiDou,Guang-BoGe,LingYang.InvitrocharacterizationoftheglucuronidationpathwaysofD-luciferinmediatedbyhumanUDP-glucuronosyltransferases.DrugMetabolismandPharmacokinetics,2017,32(1):S77
[9]WeiLei,Dan-DanWang,TongyiDou,JieHou,LiangFeng,HengYin,QunLuo,JieSun,Guang-BoGe,LingYang.Assessmentoftheinhibitoryeffectsofpyrethroidsagainsthumancarboxylesterases.ToxicologyandAppliedPharmacology,2017,321:48–56
[10]Zi-MiaoWeng,PingWang,Guang-BoGe,Zi-RuDai,Da-ChangWu,Li-WeiZou,TongyiDou,JieHou,Tong-YanZhang,LingYang.Structure-activityrelationshipsofflavonoidsasnaturalinhibitorsagainstE.coliβ-glucuronidase.FoodandChemicalToxicology,Availableonline24March2017,https://doi.org/10.1016/j.fct.2017.03.042
[11]Jing-JingWu,Yun-FengCao,LiangFeng,Yu-QiHe,JamesY.Hong,TongyiDou,PingWang,Da-ChengHao,Guang-BoGe,andLingYang.ANaturallyOccurringIsoform-SpecificProbeforHighlySelectiveandSensitiveDetectionofHumanCytochromeP4503A5,J.Med.Chem.,2017,60(9):3804–3813
[12]PingWang,Yang-LiuXia,Li-WeiZou,Xing-KaiQian,TongyiDou,QiangJin,Shi-YangLi,YangYu,Dan-DanWang,QunLuo,GuangboGe,LingYang.AnOptimizedTwo-PhotonFluorescentProbeforBiologicalSensingandImagingofCatechol-O-Methyltransferase.Chemistry,2017,23(45):10800-10807.
[13]Li-WeiZou,TongyiDou(并列第一),PingWang,WeiLei,Zi-MiaoWeng,JieHou,Dan-DanWang,Yi-MingFan,Wei-DongZhang,Guang-BoGe,LingYang,Structure-activityrelationshipsofpentacyclictriterpenoidsaspotentandselectiveinhibitorsagainsthumancarboxylesterase1,FrontiersinPharmacology,2017,8:435.

[教育背景]
2009.9--2014.12
大連理工大學(xué) 物理化學(xué) 博士

大連理工大學(xué)

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