招生人數(shù):8

課題組長簡介

周磊，男，39歲，廣西大學動物科學技術(shù)學院教授、博士生導師，副院長。入選首批廣西壯族自治區(qū)高層次人才、廣西優(yōu)秀專家、廣西“百人計劃”，獲廣西青年五四獎?wù)拢袊竽莲F醫(yī)學會動物遺傳育種學分會理事、生理生化學分會理事，農(nóng)業(yè)生物化學與分子生物學分會理事，亞熱帶農(nóng)業(yè)生物資源保護與利用國家重點實驗室固定研究人員。先后留學德國糖尿病研究中心（杜塞爾多夫）、法國原子能委員會（巴黎）、美國賓夕法尼亞大學（費城）。2013年作為學術(shù)帶頭人引進到廣西大學，建立分子營養(yǎng)課題組。廣西大學是雙一流學科建設(shè)高校，入選教育部部區(qū)合建高校。課題組隸屬國家重點實驗室和自治區(qū)一流建設(shè)學科，課題組現(xiàn)有動物代謝籠、核磁、CT等大型設(shè)備，具有生物化學和分子生物學研究的常規(guī)設(shè)備，在今后幾年的雙一流建設(shè)中還將購置近千萬的設(shè)備，實驗平臺不弱于國內(nèi)、抑或國外相關(guān)專業(yè)。課題組正在開展基因功能、高通量測序分析、小分子化合物篩選和設(shè)計（已購置Discovery Studio軟件）等工作，目前已積累非常豐富的組學數(shù)據(jù)，非常歡迎對生物、生物信息、分子模擬、化學生物學感興趣的同學加入。聯(lián)系方式：zhoulei@gxu.edu.cn。

研究方向

營養(yǎng)組學研究（功能基因組、表觀基因組、蛋白質(zhì)組、蛋白質(zhì)修飾組）

營養(yǎng)小分子的篩選、設(shè)計和功能研究

動物重要經(jīng)濟性狀的遺傳改良

動物生理代謝調(diào)控

功能基因的轉(zhuǎn)錄調(diào)控和信號轉(zhuǎn)導

社會兼職

中國畜牧獸醫(yī)學會動物遺傳育種學分會理事

中國畜牧獸醫(yī)學會動物生理生化學分會理事

農(nóng)業(yè)生物化學與分子生物學分會理事

廣西實驗動物學會常務(wù)理事

碩士生要求

1. 生物、基礎(chǔ)醫(yī)學、計算化學等相關(guān)專業(yè)

2. 對生命科學研究、對大數(shù)據(jù)分析有濃厚興趣

3. 做事認真踏實，責任心強，有良好的與人相處和溝通的能力及團隊合作精神

4. 具備良好的英語讀寫能力

相關(guān)待遇

碩士生除享有國家和課題組固定津貼，根據(jù)科研績效還享有課題組額外獎勵，優(yōu)秀的同學可申請碩博連讀。

課題組情況

分子營養(yǎng)課題組依托廣西大學動物科學技術(shù)學院和亞熱帶農(nóng)業(yè)生物資源保護與利用國家重點實驗室，研究方向為糖脂代謝調(diào)控，在醫(yī)學上主要針對肥胖、糖尿病、脂肪肝等代謝疾??；在畜牧上研究脂肪性狀對繁殖、肉質(zhì)、瘦肉率的調(diào)控。已在hepatology、nucleic acids research等高水平雜志上發(fā)表多篇論文。課題組長周老師入選廣西自治區(qū)優(yōu)秀專家、百人計劃、廣西大學杰出人才培養(yǎng)計劃，團隊承擔多項國家級、省部級研究課題。

1. 周老師從科研思路、實驗技能和論文寫作方面親自指導學生，與學生一起做研究，全方位培養(yǎng)學生

2. 課題組與美國、德國等多個課題組保持著長期合作關(guān)系，優(yōu)秀研究生和博士后根據(jù)項目進展和合作需要，有機會赴德國或美國進行聯(lián)合培養(yǎng)或合作研究，畢業(yè)或出站后盡力推薦去國外一流課題組繼續(xù)深造

3. 博士后和研究生每年至少參加一次國內(nèi)學術(shù)會議

4. 課題組工作氛圍輕松友善，為團隊成員提供實現(xiàn)自身價值的機會及發(fā)展空間

5. 先進的課題組運行模式，每個成員都有獨立項目

6. 較為充足的研究經(jīng)費（詳見主持項目）

7. 充足的實驗空間和優(yōu)良的實驗設(shè)備，具有課題組專用的細胞培養(yǎng)室和動物房

主持項目

1. 廣西科技基地和人才專項，2018/12-2021/11。

2. 國家重點研發(fā)計劃，2018/06-2020/12。

3. 廣西大學高層次專業(yè)技術(shù)人才培養(yǎng)工程“杰出人才培養(yǎng)計劃”，2015/08-2021/07。

4. 國家自然科學基金，2014/01-2016/12；2017/01-2020/12。

5. 廣西高校引進海外高層次人才“百人計劃”，2014年。

6. 廣西自然科學基金重點項目，2014/06-2017/05；2020/01-2023/12。

7. 廣西大學科研基金（引進人才項目），2013/07-2018/06。

8. 歐洲糖尿病研究基金項目（efsd，歐洲基金會資助），2012/01-2013/06。

9. 教育部博士點新教師基金，2011/01-2013/12。

10. tanita健康體重基金（日本基金會資助），2009/10-2010/10。

11. 歐洲糖尿病研究基金項目（efsd，歐洲基金會資助），2006/10-2007/03。

近年代表作

第一/通訊作者（*）

1. Lei Zhou*, Xiaolan Yu, Qingjie Meng, Hongqiang Li, Congcong Niu, Yun Jiang, Yuxi Cai, Minghui Li, Qiang Li, Chaoqiang An, Le Shu, Ao Chen, Handong Su, Yin Tang, Shen Yin, Silja Raschke, Kristin Eckardt, Juergen Eckel, Zaiqing Yang*. Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C/protein kinase G/p65/PPAR gamma coactivator 1 alpha pathway. Hepatology. 2013, 57: 1384-1393. IF：14.971

2. Lei Zhou, Gwenaelle Le Roux, Cecile Ducrot, Stephane Chedin, Jean Labarre, Michel Riva, Christophe Carles*. Repression of class I transcription by cadmium is mediated by the Protein Phosphatase 2A. Nucleic Acids Res. 2013, 41: 6087–6097. IF：11.147

3. Yixing Li, Kejing Wu, Weili Quan, Lin Yu, Shuang Chen, Chao Cheng, Qijia Wu, Shuhong Zhao, Yi Zhang*, Lei Zhou*. The dynamics of FTO binding and demethylation from the m6A motifs. RNA Biology. 2019, 16: 1179–1189. IF：5.477

4. Zupeng Luo, Zhiwang Zhang, Lina Tai, Lifang Zhang, Zheng Sun, Lei Zhou*. Comprehensive analysis of differences of N6-methyladenosine RNA methylomes between high-fat-fed and normal mouse livers. Epigenomics. 2019, 11(11): 1267-1282. IF: 4.404

5. Zhanyang Tang, Yi Zhou, Jun Xiao, Huan Zhong, Weiwei Miao, Zhongbao Guo, Xu Zhang, Lei Zhou*, Yongju Luo*. Transcriptome Analysis of Ovary Development in Nile Tilapia Under Different Photoperiod Regimes. Frontiers in Genetics. 2019, 10: 894. IF: 3.517

6. Lifang Zhang, Yilin Qi, Zhier ALuo, Siqi Liu, Zhiwang Zhang and Lei Zhou*. Betaine increases mitochondrial content and improves hepatic lipid metabolism. Food & Function. 2019, 10: 216-223. IF：3.241

7. Qiang Li, Yixing Li, Zhiwang Zhang, Huifang Kang, Lifang Zhang, Yuxiang Zhang, Lei Zhou*. SEIPIN overexpression in the liver may alleviate hepatic steatosis by influencing the intracellular calcium level. Mol Cell Endocrinol. 2019, 488: 70-78. IF：3.693

8. Li Y, Luo Z, Wu X, Zhu J, Yu K, Jin Y, Zhang Z, Zhao S, Zhou L*. Proteomic Analyses of Cysteine Redox in High-Fat-Fed and Fasted Mouse Livers: Implications for Liver Metabolic Homeostasis. J Proteome Res. 2018, 17(1): 129-140. IF：3.78

9. Kang Huifang, Zhang Zhiwang, Yu Lin, Li Yixing*, Liang Mingzhen, Zhou Lei*. FTO reduces mitochondria and promotes hepatic fat accumulationthrough RNA demethylation. Journal of Cellular Biochemistry. 2018, 119(7): 5676-5685. IF：3.448

10. Yixing Li, Huifang Kang, Yi Chu, Yi Jin, Lifang Zhang, Ranran Yang, Zhiwang Zhang, Shuhong Zhao, Lei Zhou*. Cidec differentially regulates lipid deposition and secretion through two tissue-specific isoforms. Gene. 2018, 641C: 265-271. IF：2.415

11. Lin Yu, Lina Tai, Lifang Zhang, Yi Chu, Yixing Li*, Lei Zhou*. Comparative analyses of long non-coding RNA in lean and obese pig. Oncotarget. 2017, 8(25): 41440-41450. IF：5.168

12. Yuxiang Zhang, Yixing Li, Lin Yu, Lei Zhou*. Association between serum resistin concentration and hypertension: A systematic review and meta-analysis. Oncotarget. 2017, 8(25): 41529-41537. IF：5.168

13. Yixing Li, Yi Chu, Lin Yu, Huifang Kang, Lei Zhou*. Transcriptomic analysis of Bama pig's liver in various nutritional status reveals a metabolic difference of fatty acid. Food & Function. 2017, 8: 3480-3490. Cover Paper, IF：3.241

14. Qiang Li, Yuxi Cai, Jing Huang, Xiaolan Yu, Jun Sun, Zaiqing Yang*, Zhou L*. Resistin impairs glucose permeability in EA.hy926 cells by downregulating GLUT1 expression. Mol Cell Endocrinol. 2016, 434: 127-34. IF：3.693

15. Jiang Y, Lu L, Hu Y, Li Q, An C, Yu X, Shu L, Chen A, Niu C, Zhou L*, Yang Z*. Resistin Induces Hypertension and Insulin Resistance in Mice via a TLR4-Dependent Pathway. Sci Rep. 2016, 6: 22193. IF：4.259

16. Y Li, L Zhou*, Vitamin D Deficiency, Obesity and Diabetes. Cell Mol Biol. 2015, 61(3): 35-38. IF：0.92

17. Li H, Chen A, Shu L, Yu X, Gan L, Zhou L*, Yang Z*. Translocation of CIDEC in hepatocytes depends on fatty acids. Genes Cells. 2014, 19(11): 793-802. IF：1.993

18. Lei Zhou, Lijie Zhang, Qingjie Meng, Congcong Niu, Dan Jin, An Yu, Li gan, Zaiqing Yang. C/EBP? promotes transcription of the porcine perilipin5 gene. Mol Cell Endocrinnol. 2012, 364:28-35. IF：3.693

19. Lei Zhou, Qingjie Meng, Tao Qian, Zaiqing Yang. Ginkgo biloba extract enhances glucose tolerance in hyperinsulinism-induced hepatic cells. J Nat Med. 2011, 65(1): 50-6. IF：1.982

20. Lei Zhou, Henrike Sell, Kristin Eckardt, Zaiqing Yang, Jürgen Eckel. Conditioned medium obtained from in vitro differentiated adipocytes and resistin induce insulin resistance in human hepatocytes. FEBS letters. 2007, 581: 4303-4308. IF：3.623

21. Lei Zhou, Yixing Li, Tao Nie, Shengqiu Feng, Huaping Chen, Zaiqing Yang. Clenbuterol inhibits SREBP-1c expression by activating CREB1. J BIOCHEM MOL BIOL. 2007, 40(4): 525-31. IF：2.021

22. Lei Zhou, Yixing Li, Tao Xia, Shengqiu Feng, Xiaodong Chen, Zaiqing Yang. Resistin Overexpression Impaired Glucose Tolerance in Hepatocytes. Eur Cytokine Netw. 2006, 17(3): 189-95. IF：2.364

23. Lei Zhou, Tao Xia, Yixing Li, Xiaodong Chen, Yin Peng, Zaiqing Yang. Transcriptional Regulation of the Resistin Gene. Domest Anim Endocrinol. 2006, 30(2): 98-107. IF：1.644

合作論文

24. Chen Ao, Chen Xiaodong, Cheng Shiqiang, Shu Le, Yan Meiping, Yao Lun, Wang Binyu, Huang Shuguang, Zhou Lei, Yang Zaiqing, Liu Guoquan. FTO promotes SREBP1c maturation and enhances CIDEC transcription during lipid accumulation in HepG2 cells. Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids. 2018, 1863(5): 538-548. IF：5.547

25. Yanling Wu, Qinqiang Long, Bin Feng, Xiaoyue Zhu, Zifeng Zheng, Sumin Gao, Mingju Gao, Li Gan, Lei Zhou, Zaiqing Yang. Molecular cloning and characterization of the anti-obesity gene adipose in pig. Gene. 2012, 509: 110-9. IF：2.415

26. Chen Z, Gao X, Lei T, Chen X, Zhou L, Yu A, Lei P, Zhang R, Long H, Yang Z. Molecular characterization, expression and chromosome localization of porcine PNPLA3 and PNPLA4. Biotechnol Lett. 2011, 33(7): 1327-37. IF：1.73

27. Zhang J, Lei T, Chen X, Peng Y, Long H, Zhou L, Huang J, Chen Z, Long Q, Yang Z. Resistin Up-Regulates COX-2 Expression via TAK1-IKK-NF-kappaB Signaling Pathway. Inflammation. 2010, 33(1): 25-33. IF：2.955

28. Qi YM, Lei T, Zhou L, Chen XD, Long QQ, Long H, Jin D, Gan L, Yang ZQ. Genomic organization, alternative splicing and tissues expression of porcine CREB3L4 gene. Mol Biol Rep. 2009, 36(7): 1881-8. IF：1.828

29. Y. H. Li, T. Lei, X. D. Chen, T. Xia, Q. Q. Long, J. Zhang, S. Q. Feng, Y. Peng, L. Zhou, Z. Q. Yang. Molecular cloning, chromosomeal location and expression pattern of porcine CIDEa and CIDEc. Mol Biol Rep. 2009, 36(3): 575-82. IF：1.828

30. Qi M, Lei T, Zhou L, Chen XD, Long H, Long QQ, Zhang RR, Yang ZQ, Gan L. Cloning, Characterization, Chromosomal Mapping and Tissue Transcription Analysis of Porcine CREB2 and CREB3 Genes. Folia Biol. 2009, 55(4): 137-44. IF：0.939

31. Huaping Chen, Wenshu Yao, Dan Jin, Tao Xia, Xiaodong Chen, Ting Lei, Lei Zhou, Zaiqing Yang. Cloning, Expression Pattern, Chromosomal Localization, and Evolution Analysis of Porcine Gnaq, Gna11, and Gna14. Biochem Genet. 2008, 46(7-8): 398-405. IF：1.543

32. Y Li, L Zhou, Y Li, D Chen, X Tan, L Lei and J Zhou. A Nodule-Specific Plant Cysteine Proteinase, AsNODF32, Is Involved in Nodule Senescence and Nitrogen Fixation Activity of the Green Manure Legume Astragalus sinicus. New Phytologist. 2008, 180: 185-192. IF：7.33

33. Huaping Chen, Tao Xia, Lei Zhou, Xiaodong Chen, Li Gan, Wenshu Yao, Yin Peng, and Zaiqing Yang. Gene organization, alternate splicing and expression pattern of porcine visfatin gene. Domest Anim Endocrinol. 2007; 32: 235-45. IF：1.644

34. HW Yang, T Xia, ZL Chen, SQ Feng, Y Peng, L Zhou, L Gan, and ZQ Yang. Cloning, chromosomal localization and expression patterns of porcine Kruppel-like factors 4, -5, -7 and the early growth response factor 2. Biotechnol Lett. 2007; 29(1): 157-63. IF：1.73

35. Feng SQ, Chen XD, Xia T, Gan L, Qiu H, Dai MH, Zhou L, Peng Y, Yang ZQ. Cloning, chromosome mapping and expression characteristics of porcine ANGPTL3 and -4. Cytogenet Genome Res. 2006; 114(1): 44-9. IF：1.354

考研調(diào)劑信息提示：本文內(nèi)容轉(zhuǎn)載自小木蟲論壇，由學校導師實驗室自行發(fā)布，信息準確度有待考量，請廣大考生謹慎選擇。點擊查看原文