山東大學(xué)生命科學(xué)學(xué)院導(dǎo)師：陳敏 正文

　　陳敏 副教授 博士
　　通訊地址：250100，山東大學(xué) 生命科學(xué)學(xué)院 微生物技術(shù)國(guó)家重點(diǎn)實(shí)驗(yàn)室糖科學(xué)技術(shù)實(shí)驗(yàn)室
　　聯(lián)系方式：0531-88366078
　　E-mail: chenmin@sdu.edu.cn
　　
　　研究方向
　　微生物糖生物學(xué)和糖生物化學(xué)
　　
　　研究項(xiàng)目
　　曾先后承擔(dān)或參加項(xiàng)目5項(xiàng)(其中2項(xiàng)參加人，3項(xiàng)主持人) , 主持橫向課題一項(xiàng)?；谵D(zhuǎn)基因植物的大腸桿菌志賀氏毒素口服疫苗研究 (山東省醫(yī)藥衛(wèi)生科研項(xiàng)目, 2007—2009，課題主持人)。干擾素-β的糖基化改造研究(山東省優(yōu)秀中青年科學(xué)家科研獎(jiǎng)勵(lì)基金, 2005-2007，課題主持人), 細(xì)胞色素P450和谷胱甘肽-S-轉(zhuǎn)移酶基因共表達(dá)農(nóng)藥降解基因工程菌的研究( 國(guó)家高技術(shù)研究發(fā)展計(jì)劃（863計(jì)劃），2008-2010, 子課負(fù)責(zé)人), 糖基化改造的干擾素-β研究與應(yīng)用(橫向課題, 2005-2007, 課題主持人),糖生物學(xué)I－糖酰胺酶的研究與應(yīng)用(30470399))(國(guó)家自然科學(xué)基金, 2004-2007, 主要參加人), 利用化學(xué)生物酶法合成巖藻糖基化寡糖及其水凝膠聚合物在醫(yī)學(xué)中的應(yīng)用(20572063) (國(guó)家自然科學(xué)基金, 2005-2008, 主要參加人) 。
　　
　　申請(qǐng)專利
　　1.鈉/質(zhì)子反向轉(zhuǎn)運(yùn)器基因及其編碼的蛋白質(zhì)，專利號(hào): 02146310
　　2.用酵母表達(dá)、生產(chǎn)及糖基化改造人干擾素－β的方法,專利申請(qǐng)?zhí)? 200510045207.1
　　
　　近年發(fā)表論文：
　　1．Zhong Zhuang, Zhi-Gang Wu, Min Chen* and Peng George Wang.Secretion of human interferon-B 1b by recombinant Lactococcus lactis, Biotechnology Letters (2008), 30(10), 1819-1823.
　　2．Jie Shen, Robert Woodward, James Patrick Kedenburg, Xianwei Liu, Min Chen, Lanyan Fang, Duxin Sun, and Peng George Wang，Histone Deacetylase Inhibitors through Click Chemistry，J. Med. Chem., 2008, 51 (23), 7417-7427
　　3．Min. Chen, Qi.-Jun. Chen, Xu.-Guang. Niu, Rong. Zhang, Hui.-Qiong. Lin, Chun.-Ying. Xu, Xue.-Chen. Wang, Gou.-Ying. Wang, Ja. Chen, Expression of OsNHX1 gene in maize confers salt tolerance and promotes plant growth in the field，PLANT SOIL ENVIRON. 2007,53, (11): 490–498
　　4．zhao, Guohui; Liu, Jun; Liu, Xiang; Chen, Min; Zhang, Houcheng; Wang, Peng George. Cloning and characterization of GDP-perosamine synthetase (Per) from Escherichia coli O157 :H7 and synthesis of GDP-perosamine in vitro. Biochemical and Biophysical Research Communications , 2007, 363(3), 525-530.
　　5．Su, Yishan; Zhang, Houcheng; Gu, Li; Chen, Min; Xiao, Min; Wang, Peng George; Qi, Qingsheng. Engineered yeast with PNGase F on cell surface for releasing of N-glycans from glycoproteins. Enzyme and Microbial Technology (2007), 40(6), 1496-1502.
　　6．Wang Qing jie , Li Lei, Chen M, Qi Qingsheng, Wang Peng George.Construction of a novel system for cell surface display of heterologous proteins on Pichia pastoris，Biotechnol Lett. 2007, 29(10):1561-6.
　　7 ．Jing Li, Min Chen*, Xian-Wei Liu, Hou-Cheng Zhang, Fa Fu Shen, Peng George Wang, Transient expression of an active human interferon-beta in lettuce, Scientia Horticulturae, 2007,112:258–265
　　8．Jing Li; Min Chen*; Xianwei Liu; Fafu Shen, Peng George Wang *, A Highly Efficient System Establishment of Transient Expression in Lettuce, Acta Horticulturae Sinica, 2006, 33 (2) : 405～407 (in Chinese)
　　9．Jing Song, Kang Ryu, Min Chen, Wei Wang , Hanfen Li , Wen Yi , Peng George Wang，Enzymatic Biosynthesis of Oligosaccharides and Glycoconjugates，Current Organic Synthesis, 2006, 3, 19-39.
　　10．Yu-Ye Wu, Qi-Jun Chen, Min Chen, Jia Chen and Xue- Chen Wang ，Salt-tolerant transgenic perennial ryegrass (Lolium perenne L.) obtained by Agrobacterium tumefaciens-mediated transformation of the vacuolar Na+/H+ antiporter gene, Plant Science, 2005, 169(1): 65-73
　　11．Min Chen, Xianwei Liu, Zhankun Wang, Qingsheng Qi, Peng George Wang, Modification of plant N-glycans processing—The Future of Producing Therapeutic Protein by Transgenic Plants, Medicinal Research Reviews, 2005, 25(3):343-360
　　12．Min Chen, Qi-Jun Chen, Mao feng Cai, Guo ming Shen, Jia Chen and Xue- Chen Wang, Cloning and characterization of Na+/H+ antiporter gene in zea mays，2005，High technology letter, 15(169):62-65 (in Chinese)
　　13．Min Chen, Dehu Liu, Peng George Wang ,Progresses in glycosylation of transgenic plants and the strategies for Modifying N-glycans of glycoproteins, High technology letter, 2005,15(172):107-110 (in Chinese)

　　* Corresponding author
　　Book
　　Ryu, Kang; Lin, Steven; Shao, Jun; Song, Jing; Chen, Min; Wang, Wei; Li, Hanfen; Yi, Wen; Wang, Peng George. “Synthesis of complex carbohydrates and glyconjugates: Enzymatic synthesis of globotetraose using ?-1,3-N-acetylgalactosaminyltransferase LgtD from Haemophilus infuenzae strain Rd.” Methods in Molecular Biology (Totowa, NJ, United States) 2005, 310(Chemical Genomics), 93-105.

　　*如果發(fā)現(xiàn)導(dǎo)師信息存在錯(cuò)誤或者偏差，歡迎隨時(shí)與我們聯(lián)系，以便進(jìn)行更新完善。

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