山東大學(xué)生命科學(xué)學(xué)院導(dǎo)師：盛多紅 正文

　　盛多紅，博士，山東大學(xué)微生物技術(shù)國(guó)家
　　重點(diǎn)實(shí)驗(yàn)室研究人員。
　　
　　聯(lián)系方式：
　　地址：山東濟(jì)南山大南路27號(hào)，250100
　　電話(huà)：13658612032
　　郵箱：dhsheng@sdu.edu.cn
　　
　　學(xué)習(xí)工作簡(jiǎn)歷：
　　1991．9-1995．7 山東大學(xué)微生物學(xué) 本科
　　1995．9-1998．7 中科院武漢病毒所微生物學(xué) 碩研
　　1998．7-2002．3 山東省科學(xué)院和Medgenn公司 科研人員
　　2002．3-2005．3 浙江大學(xué)生物物理學(xué) 博研
　　2005．7-至今 山東大學(xué)生命科學(xué)學(xué)院講師、副教授
　　
　　研究方向：圍繞微生物生理代謝過(guò)程，研究DNA重組修復(fù)機(jī)制，分析其在細(xì)菌耐藥性發(fā)生中的作用。

　　已發(fā)表DNA修復(fù)相關(guān)論文：
　　Wang L, Sheng D, Han W, Huang B, Zhu S, Ni J, Li J, Shen Y. Sulfolobus tokodaii RadA paralog, stRadC2, is involved in DNA recombination by interacting with RadA and Hjc. Sci China C Life Sci. 2012.（并列第一）
　　Hong Y, Chu M, Li Y, Ni J, Sheng D, Hou G, She Q, Shen Y. Dissection of the functional domains of an archaeal Holliday junction helicase. DNA Repair (Amst). 2012, 11(2):102-111.
　　Wei T, Zhang S, Hou L, Ni J, Sheng D, Shen Y. The carboxyl terminal of the archaeal nuclease NurA is involved in the interaction with single-stranded DNA-binding protein and dimer formation. Extremophiles. 2011, 15(2):227-234.
　　Ma X, Hong Y, Han W, Sheng D, Ni J, Hou G, Shen Y. Single-stranded DNA binding activity of XPBI, but not XPBII, from Sulfolobus tokodaii causes double-stranded DNA melting. Extremophiles 2011, 15(1):67-76.
　　Sheng D, Li M, Jiao J, Sheng X, Deng W, Hua Y. Repression of recA induction by RecX is independent of the RecA protein in Deinococcus radiodurans. J Bacteriol. 2010, 192(13):3540-4.
　　Wu L, Liu B, Hong Y, Sheng D, Shen Y, Ni J. Residue Tyr224 is critical for the thermostability of Geobacillus sp. RD-2 lipase. Biotechnol Lett. 2010, 32(1):107-12.
　　Sheng D, Jao J, Li M, Xu P, Zhang J. RecX is involved in the switch between DNA damage response and normal metabolism in D. radiodurans. J Biochem. 2009, 146(3):337-42.
　　Sheng D, Li M, Jiao J, Ni J, Shen Y. Co-expression with RadA and the characterization of stRad55B, a RadA paralog from the hyperthermophilic crenarchaea Sulfolobus tokodaii. Sci China C Life Sci. 2008, 51(1):60-5.
　　Sheng D, Zhu S, Wei T, Ni J, Shen Y. The in vitro activity of a Rad55 homologue from Sulfolobus tokodaii, a candidate mediator in RadA-catalyzed homologous recombination. Extremophiles 2008, 12(1):147-57.
　　Sheng D, Zhu S, Li M, Jiao J, Ni J, Shen Y. Cloning, expression and radiation inducibility of RadA from the hyperthermophilic archaeon Sulfolobus tokodaii. Wei Sheng Wu Xue Bao 2008, 48(3):317-22.
　　Lu S, Li Z, Wang Z, Ma X, Sheng D, Ni J, Shen Y. Spatial subunit distribution and in vitro functions of the novel trimeric PCNA complex from Sulfolobus tokodaii. Biochem Biophys Res Commun. 2008, 376(2):369-74.
　　Li Z, Lu S, Hou G, Ma X, Sheng D, Ni J, Shen Y. Hjm/Hel308A DNA helicase from Sulfolobus tokodaii promotes replication fork regression and interacts with Hjc endonuclease in vitro. J Bacteriol. 2008, 190(8):3006-17.
　　Zhang S, Wei T, Hou G, Zhang C, Liang P, Ni J, Sheng D, Shen Y. Archaeal DNA helicase HerA interacts with Mre11 homologue and unwinds blunt-ended double-stranded DNA and recombination intermediates. DNA Repair (Amst) 2008, 7(3):380-91.
　　Wei T, Zhang S, Zhu S, Sheng D, Ni J, Shen Y. Physical and functional interaction between archaeal single-stranded DNA-binding protein and the 5'-3' nuclease NurA. Biochem Biophys Res Commun. 2008, 367(3):523-9.
　　Liu B, Hong Y, Wu L, Li Z, Ni J, Sheng D, Shen Y. A unique highly thermostable 2-phosphoglycerate forming glycerate kinase from the hyperthermophilic archaeon P. horikoshii: gene cloning, expression and characterization. Extremophiles 2007, (5):733-9.
　　Liu B, Li Z, Hong Y, Ni J, Sheng D, Shen Y. Cloning, expression and characterization of a thermostable exo-beta-D-glucosaminidase from the hyperthermophilic archaeon Pyrococcus horikoshii. Biotechnol Lett. 2006, 28(20):1655-60.
　　Tian B, Zhang SW, Xu ZJ, Sheng DH, Hua YJ. Effects of PprI and RecX on antioxidant activity of Deinococcus radiodurans. Wei Sheng Wu Xue Bao 2006, 46(2):238-42.
　　Sheng D, Liu R, Xu Z, Singh P, Shen B, Hua Y. Dual negative regulatory mechanisms of RecX on RecA functions in radiation resistance, DNA recombination and consequent genome instability in Deinococcus radiodurans.DNA Repair (Amst) 2005, 4(6):671-8.
　　Sheng D, Gao G, Tian B, Xu Z, Zheng Z, Hua Y. RecX is involved in antioxidant mechanisms of the radioresistant bacterium Deinococcus radiodurans. FEMS Microbiol Lett. 2005, 244(2):251-7.
　　Sheng D, Zheng Z, Tian B, Shen B, Hua Y. LexA analog (dra0074) is a regulatory protein that is irrelevant to recA induction. J Biochem. 2004, 136(6):787-93.
　　Zhang C, Wei J, Zheng Z, Ying N, Sheng D, Hua Y. Proteomic analysis of Deinococcus radiodurans recovering from gamma-irradiation. Proteomics 2004, 5(1):138-143
　　Tian B, Wu Y, Sheng D, Zheng Z, Gao G, Hua Y. Chemiluminescence assay for reactive oxygen species scavenging activities and inhibition on oxidative damage of DNA in Deinococcus radiodurans. Luminescence 2004, 19(2):78-84
　　Gao G, Tian B, Liu L, Sheng D, Shen B, Hua Y. Expression of Deinococcus radiodurans PprI enhances the radioresistance of Escherichia coli. DNA Repair (Amst) 2003, 2(12):1419-27.

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