山東大學(xué)生命科學(xué)學(xué)院導(dǎo)師：趙小凡 正文

　　趙小凡 教授
　　博士生導(dǎo)師
　　電話；0531-88364620
　　E-mail:xfzhao@sdu.edu.cn
　　 
　　教育背景
　　從事昆蟲(chóng)生理生化與分子生物學(xué)研究，重點(diǎn)研究昆蟲(chóng)發(fā)育過(guò)程中蛻皮與變態(tài)的功能基因和分子調(diào)控機(jī)理。承擔(dān)本科生和研究生教學(xué)工作。1990-1991年赴日本從事家蠶半胱氨酸蛋白酶研究；1998-2000年獲德國(guó)政府學(xué)術(shù)交流會(huì)（DAAD）“生物科學(xué)特別項(xiàng)目博士后獎(jiǎng)學(xué)金”赴德國(guó)從事煙草天蛾V-ATP酶研究；2001-2002年在日本九州工業(yè)大學(xué)從事DNA和蛋白質(zhì)測(cè)序、基因重組蛋白包涵體復(fù)性和純化、畢赤酵母表達(dá)外源基因等研究；2003年獲德國(guó)政府德意志聯(lián)合研究會(huì)（DFG）資助赴德國(guó)從事基因重組病毒殺蟲(chóng)劑構(gòu)建和蛋白酶、HHR3在昆蟲(chóng)細(xì)胞中的表達(dá)等研究。2005年赴日本從事蛋白質(zhì)組學(xué)研究。2006年赴美國(guó)密蘇里大學(xué)進(jìn)行短期科研工作。先后承擔(dān)國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目、重大國(guó)際合作項(xiàng)目和面上項(xiàng)目；參加國(guó)家“973”和“863”項(xiàng)目；以及承擔(dān)山東省自然科學(xué)基金重點(diǎn)項(xiàng)目等科研項(xiàng)目10余項(xiàng)。主要學(xué)術(shù)成果有：從棉鈴蟲(chóng)鑒定并純化到組織蛋白酶B，克隆到該蛋白酶基因（HCB），闡明了該蛋白酶在棉鈴蟲(chóng)生長(zhǎng)發(fā)育中的功能，從大豆等植物種子中鑒定并純化到該蛋白酶的抑制因子，對(duì)腫瘤細(xì)胞有抑制生長(zhǎng)的作用；克隆了棉鈴蟲(chóng)蛻皮調(diào)節(jié)轉(zhuǎn)錄因子HHR3基因并闡明了該基因的表達(dá)和激素調(diào)控模式；闡明了多種棉鈴蟲(chóng)幼蟲(chóng)蛻皮和變態(tài)時(shí)期差異表達(dá)的蛋白質(zhì)和基因，為研究昆蟲(chóng)發(fā)育的分子機(jī)制提供了新靶標(biāo)；證明了非甾醇類(lèi)蛻皮激素競(jìng)爭(zhēng)物（RH-2485）可以導(dǎo)致棉鈴蟲(chóng)致死性提前蛻皮，可用于田間控制棉鈴蟲(chóng)；構(gòu)建了HCB和HHR3基因重組核型多角體病毒，可用于開(kāi)發(fā)高技術(shù)生物殺蟲(chóng)劑用于害蟲(chóng)控制。獲得國(guó)家發(fā)明專(zhuān)利多項(xiàng)。濟(jì)南市第十二屆、第十三屆、第十四屆人大代表。
　　 
　　研究方向
　　研究生招生專(zhuān)業(yè)：生化與分子生物學(xué)
　　研究方向：昆蟲(chóng)生化與分子生物學(xué)
　　研究?jī)?nèi)容：以棉鈴蟲(chóng)為材料，用分子生物學(xué)方法研究昆蟲(chóng)蛻皮與變態(tài)的分子機(jī)理，包括：蛻皮激素信號(hào)轉(zhuǎn)導(dǎo)途徑、蛻皮與變態(tài)功能基因的表達(dá)與調(diào)控、變態(tài)發(fā)育中組織重建的分子機(jī)理、血細(xì)胞在變態(tài)發(fā)育中的功能等。
　　Research interest: We use the cotton bollworm (Helicoverpa armigera) as a model to investigate the mechanism of insect molting and metamorphosis by molecular methods. Recent studies include: 20-OH-ecdysteroid hormone signal transduction pathway; expression and regulation of molting and metamorphosis related genes; molecular mechanism of tissue remodeling; and function of haemocytes in molting and metamorphosis.
　　
　　在研課題
　　1. 昆蟲(chóng)血細(xì)胞在變態(tài)中的功能和作用機(jī)理, 國(guó)家自然科學(xué)基金。
　　2. 害蟲(chóng)暴發(fā)成災(zāi)的遺傳與行為機(jī)理，國(guó)家重大基礎(chǔ)研究項(xiàng)目973。

　　已完成課題
　　14. 棉鈴蟲(chóng)皮層溶離中蛋白酶表達(dá)及調(diào)控研究，國(guó)家自然科學(xué)基金, 2007.1-2009.12。項(xiàng)目負(fù)責(zé)人。
　　13. 重大農(nóng)業(yè)害蟲(chóng)猖獗危害的機(jī)制及可持續(xù)控制的基礎(chǔ)研究——害蟲(chóng)生長(zhǎng)發(fā)育與生殖調(diào)控的分子機(jī)制。國(guó)家重大基礎(chǔ)研究項(xiàng)目（973）。2006.1-2010.12。參加。
　　12. 家蠶重要經(jīng)濟(jì)性狀功能基因克隆，國(guó)家高技術(shù)研究發(fā)展計(jì)劃（863計(jì)劃）2006. 1-2010.12。參加。
　　11．昆蟲(chóng)蛻皮激素信號(hào)轉(zhuǎn)導(dǎo)途徑研究,國(guó)家自然科學(xué)基金重大國(guó)際合作項(xiàng)目, 2008.1-2011.12月。項(xiàng)目負(fù)責(zé)人。
　　10. 棉鈴蟲(chóng)蛻皮級(jí)聯(lián)反應(yīng)功能基因表達(dá)研究, 國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目，2004.1-2007.12。項(xiàng)目負(fù)責(zé)人。
　　9. 基因重組病毒殺蟲(chóng)劑研究,山東省自然科學(xué)基金重點(diǎn)項(xiàng)目,2004.1-2006.12. 項(xiàng)目負(fù)責(zé)人。
　　8. 重組病毒殺蟲(chóng)劑的研制，863，國(guó)家科技部, 2001-2004. 項(xiàng)目負(fù)責(zé)人。
　　7. 棉鈴蟲(chóng)蛻皮調(diào)節(jié)轉(zhuǎn)錄因子基因克隆和表達(dá)載體構(gòu)建,國(guó)家自然科學(xué)基金,2001.1-2003.1. 項(xiàng)目負(fù)責(zé)人。
　　6. 棉鈴蟲(chóng)卵蛋白酶基因克隆及功能表達(dá), 國(guó)家自然科學(xué)基金, 1999.1-2001.12. 項(xiàng)目負(fù)責(zé)人。
　　5. RH-化合物對(duì)棉鈴蟲(chóng)的防治效果研究, 山東省科委國(guó)際合作基金, 1998.1-2000.12. 項(xiàng)目負(fù)責(zé)人。
　　4. 蛻皮激素類(lèi)似物合成及對(duì)棉鈴蟲(chóng)的防治研究, 山東省科委優(yōu)秀年輕教師獎(jiǎng)勵(lì)基金,1999.1-2000.12. 項(xiàng)目負(fù)責(zé)人。
　　3. 棉鈴蟲(chóng)卵內(nèi)蛋白酶純化, 國(guó)家自然科學(xué)基金主任基金, 1998.1-12. 項(xiàng)目負(fù)責(zé)人。
　　2. 鱗翅目昆蟲(chóng)卵內(nèi)蛋白酶純化性質(zhì)與cDNA克隆. 國(guó)家教育部?jī)?yōu)秀年輕教師基金, 1996.1-1998.12. 項(xiàng)目負(fù)責(zé)人。
　　1. 蓖麻蠶卵黃蛋白質(zhì)降解酶研究，國(guó)家教育部留學(xué)回國(guó)人員基金，1992.1-1994.12. 項(xiàng)目負(fù)責(zé)人。
　　
　　研究成果及發(fā)表論文
　　代表性論文：*為通訊作者，下劃線為并列作者。
　　63. Wang Chuan-Xu, Zheng Wei-Wei,Liu Peng-Cheng, Wang Jin-Xing, Zhao Xiao-Fan*, 2012, The steroid hormone 20-hydroxyecdysone upregulated the protein phosphatase 6 for the programmed cell death in the insect midgut. Amino Acids. DOI 10.1007/s00726-011-1159-9.
　　62. Dong Du-Juan, Liu Peng-Cheng,Wang Jin-Xing, Xiao-Fan Zhao*, 2012, The knockdown of Ha-GRIM-19 by RNA interference induced programmed cell death. Amino Acids. 42(4):1297-307.
　　61. He Hong-Juan, Hou Li, Wang Jin-Xing,Zhao Xiao-Fan*, 2012, The apoptosis inhibitor survivin prevents insect midgut from cell death during postembryonic development. Molecular Biology Report. 39(2):1691-9.
　　60. Zhang Feng-Xia, Shao Hong-Lian, Wang Jin-Xing, Zhao Xiao-Fan*, 2011,b-thymosin is upregulated by the steroid hormone 20-hydroxyecdysone and microorganisms.Insect Molecular Biology. 20, 519–527.
　　59. Liu Peng-Cheng, Wang Jin-Xing, Song Qi-Sheng, Zhao Xiao-Fan*, 2011, The participation of calponin in the crosstalk between 20-Hydroxyecdysone and juvenile hormone signaling pathways by phosphorylation variation. PLoS ONE. 6: e19776.
　　58. Wang Gang, Liu Peng-Cheng, Wang Jin-Xing, Zhao Xiao-Fan*, 2011, A BTBdomain-containinggeneis upregulatedby immunechallenge. Archives of Insect Biochemistry and Physiology. 77:58-71.
　　57. Yang Xiao-Hui, Liu Peng-Cheng, Zheng Wei-Wei, Wang Jin-Xing, Zhao Xiao-Fan*, 2011, The juvenile hormone analogue methoprene up-regulates the Ha-RNA-binding protein. Molecular and Cellular Endocrinology 333: 172–180.
　　56. Hou Li, Wang Jin-Xing, Zhao Xiao-Fan*, 2010, Rab32 and the remodeling of the imaginal midgut in Helicoverpa armigera. Amino Acids, DOI 10.1007/s00726-010-0720-2.
　　55. Wang Qian, Liu Yang, He Hong Juan, Zhao Xiao-Fan*, Jin-Xing Wang*, 2010, Immune response of Helicoverpa armigera to different kinds of pathogens. BMC Immunology. 11:9.
　　54. Wang Jia-Lin, Wang Li-fu, Wang Jin-Xing, Zhao Xiao-Fan*, 2010, The expression patterns of a eukaryotic initiation factor 3 subunit h in the silk glands in Bombyx mori. Archives of insect biochemistry and physiology. 75:1-12.
　　53. He Hong-Juan, Wang Qian, Zheng Wei-Wei, Wang Jin-Xing, Song Qi-Sheng, Zhao Xiao-Fan*, 2010, Function of Nuclear Transport Factor 2 and Ran in the 20E signal transduction pathway in the Cotton Bollworm, Helicoverpa armigera. BMC Cell Biology. 11:1.
　　52. Wang Li-Fu, Chai Lian-Qin, He Hong-Juan, Wang Qian, Wang Jin-Xing, Zhao Xiao-Fan*, 2010, The cathepsin L-like proteinase is involved in molting and metamorphosis in Helicoverpa armigera. Insect Molecular Biology, 19:99-111.
　　51. Zheng Wei-Wei, Yang Dan-Tong, Wang Jin-Xing, Song Qi-Sheng, Gilbert Lawrence I., Zhao Xiao-Fan*, 2010, Hsc70 binds to ultraspiracle resulting in the upregulation of 20-hydroxyecdsone-responsive genes in Helicoverpa armigera. Molecular and Cellular Endocrinology. 315: 282-291.
　　50. Fu Qiang, Liu Peng-Cheng, Wang Jin-Xing, Song Qi-Sheng, Zhao Xiao-Fan*, 2009, Proteomic identification of differentially expressed and phosphorylated proteins in epidermis involved in larval-pupal metamorphosis of Helicoverpa armigera. BMC Genomics. 10:600.
　　49. Liu Yang, Sui Yi-Peng, Wang Jin-Xing and Zhao Xiao-Fan*, 2009, Characterization of the trypsin-like protease (ha-tlp2) constitutively expressed in the integument of the cotton bollworm, Helicoverpa armigera. Archives of Insect Biochemistry and Physiology. 72:74-87.
　　48. Sui Yi-Peng, Wang Jin-Xing and Zhao Xiao-Fan*, 2009, The impacts of classical insect hormones on the expression profiles of a new digestive trypsin-like protease (TLP) from the cotton bollworm, Helicoverpa armigera. Insect Molecular Biology. 18: 443-452.
　　47. Sui Yi-Peng, Liu Xiao-Bin, Chai Lian-Qin, Wang Jin-Xing, Zhao Xiao-Fan*, 2009, Characterization and influences of classical insect hormones on the expression profiles of a molting carboxypeptidase A from the cotton bollworm (Helicoverpa armigera). Insect Molecular Biology, 18: 353–363.
　　46. Dong Du-Juan, Wang Jin-Xing, Zhao Xiao-Fan*. 2009, A eukaryotic initiation factor 5C is upregulated during metamorphosis in the cotton bollworm, Helicoverpa armigera. BMC Developmental Biology. 9:19.
　　45. Wang Jia-Lin, Zhang Ya-Ping, Gu Yin-Yu, Wang Jin-Xing and Zhao Xiao-Fan*, 2009, Function of a TGF-inducible nuclear protein in the silk gland in Bombyx mori. Insect Molecular Biology.18: 243–251.
　　44. Tian Yuan-Yuan, Liu Yang, Zhao Xiao-Fan*, Wang Jin-Xing*, 2009, Characterization of a C-type lectin from the cotton bollworm, Helicoverpa armigera. Developmental and Comparative Immunology. 33:772–779.
　　43. Shao Hong-Lian, Zheng Wei-Wei, Liu Peng-Cheng, Wang Qian, Wang Jin-Xing, Zhao Xiao-Fan*, 2008, Establishment of a New Cell Line from Lepidopteran Epidermis and Hormonal Regulation on the Genes. PLoS ONE 3: e3127.
　　42. Sui Yi-Peng, Wang Jin-Xing and Zhao Xiao-Fan*, 2008, Effects of classical insect hormones on the expression profiles of a lipase gene from the cotton bollworm (Helicoverpa armigera). Insect Molecular Biology. 17: 523 – 529.
　　41. Shao Hong-Lian, Dong Du-Juan, Hu Jin-Dong, Wang Jin-Xin, Zhao Xiao-Fan*, 2008, Construction of the recombinant baculovirus AcMNPV with cathepsin B-like proteinase and its insecticidal activity against Helicoverpa armigera. Pesticide Biochemistry and Physiology. 91:141-161.
　　40. Wang Jia-Lin, Wang Jin-Xing，Zhao Xiao-Fan*, 2008, Molecular Cloning and Expression Profiles of the Acyl-CoA-Binding Protein Gene From the Cotton Bollworm Helicoverpa armigera. Archives of Insect Biochemistry and Physiology. 68:79–88.
　　39．Chai Lian-Qin, Tian Yuan-Yuan, Yang Dan-Tong, Wang Jin-Xing, Zhao Xiao-Fan*, 2008, Molecular cloning and characterization of a C-type lectin from the cotton bollworm, Helicoverpa armigera. Developmental & Comparative Immunology, 32:71-83.
　　38．Yang Dan-Tong, Chai Lian-Qin, Wang Jin-Xing, Zhao Xiao-Fan*, 2008, Molecular cloning and characterization of Hearm caspase-1 from Helicoverpa armigera. Molecular Biology Report. 35:405-12.
　　37. Yang Xiao-Mei, Hou Li-Jing, Wang Jin-Xing, Zhao Xiao-Fan*, 2007, Expression and Function of Cathepsin B-Like Proteinase in Larval Hemocytes of Helicorverpa armigera during Metamorphosis. Archives of Insect Biochemistry and Physiology. 64:164–174.
　　36. Hu Jindong, Shao Honglian, Zhang Yubao, Fu Qiang, Sun Chen，Wang Jinxing, Zhao Xiaofan*，2007，Construction of HaSNPV with Helicoverpa hormone receptor 3. High Technology Letters, 3：327-331.
　　35. Shao Hong-Lian，Dong Du-Juan，Hu Jin-Dong，Zhang Xin-Chang，Zhang Yu-Bao，F(xiàn)u Qiang，Sun Chen，Wang Jin-Xin，Zhao Xiao-Fan*, 2007, Reconstruction of AcMNPV with Helicoverpa hormone receptor 3 and its effect on the Helicoverpa larvae. Biocontrol Science and Technology. 17: 95-104.
　　34. Dong Du-Juan1, He Hong-Juan1, Chai Lian-Qin1, Jiang Xiao-Juan, Wang Jin-Xing, Zhao Xiao-Fan*, 2007, Identification of genes differentially expressed during larval molting and metamorphosis of Helicoverpa armigera. BMC Developmental Biology, 7:73.
　　33．Wang Jia-Lin, Jiang Xiao-Juan, Wang Qian, Hou Li–Jing, Xu Da-Wei, Wang Jin-Xing, Zhao Xiao-Fan*, 2007, Identification and expression profile of a putative basement membrane protein gene in the midgut of Helicoverpa armigera. BMC Developmental Biology, 7:76.
　　32. Zhang Xin-Chang, Shao Hong-Lian, Wang Jin-Xing, Zhao Xiao-Fan*, 2006, Purification of an inhibitor of Helicoverpa cathepsin B-like proteinase from sunflower seed. Journal of Enzyme Inhibition and Medicinal Chemistry, 21: 433–439.
　　31. Yang Xiao-Mei, Hou Li-Jing, Dong Du-Juan, Shao Hong-Lian, Wang Jin-Xing, Zhao Xiao-Fan*, 2006, Cathepsin B-Like Proteinase Is Involved in the Decomposition of the Adult Fat Body of Helicoverpa armigera. Archives of Insect Biochemistry and Physiology, 62:1-10.
　　30. Zhao Xiao-Fan*, He Hong-Juan, Dong Du-Juan, Wang Jin-Xing. 2006, Identification of Differentially Expressed Proteins during Larval Molting of Helicoverpa armigera. Journal of Proteome Research, 5:164-169.

　　29．Zhao Xiao-Fan*, An Xiao-Meng, Wang Jin-Xing, Dong Du-Juan, Du Xin-Jun, Sueda S. and Kondo H., 2005，Expression of Helicoverpa cathepsin B-like proteinase during embryonic development，Archives of Insect Biochemistry and Physiology, 58: 39-46.
　　28．Zhao Xiao-Fan*, Wang Jin-Xing, Li Fei-Xue, Sueda Shinji, Kondo Hiroki. 2005，Analysis of substrate specificity and endopeptidyl cleavage sites of the cathepsin B-like proteinase from Helicoverpa armigera, The Protein Journal, 24:219 – 225.
　　27．Zhao Xiao-fan*, Wang Jin-Xing, Xu Xia-Lian, Li Zhao-Min, Kang Cui-Jie, 2004，Molecular cloning and expression patterns of molt-regulating transcription factor-hhr3 from Helicoverpa armigera. Insect Molecular Biology.13:407-412.
　　26. Zhao Xiaofan*, Li Zhaomin, Wang Jinxing, Wang Jiabao, Wang Shengli, Blankespoor D. Harvey, 2003, Efficacy of RH-2485, a new non-steroidal ecdysone agonist, against cotton bollworm, Helicoverpa armigera (lepidoptera: noctuidae) in laboratory and field. Crop Protection. 22：959-965.
　　25. Zhao X-F*, Wang J-X, Xu X-L, Schmid R., Wieczorek H., 2002，Molecular cloning and characterization of the cathepsin B-like proteinase from the cotton boll worm, Helicoverpa armigera. Insect Molecular Biology. 11: 567-575.
　　24. Merzendorfer H.，Reineke S.，Zhao X-F, Jacobmeier B., Harvey W.R., Wieczorek H., 2000，The multigene family of the tobacco hornworm V-ATPase: novel subunits a, C, D, H, and putative isoforms. Biochemica et Biophysica Acta. 1467:369-379.
　　23．Zhao Xiao-Fan*, Wang Jin-Xing, Wang Yin-Chang，1998, Purification and characterization of a cysteine proteinase from eggs of the cotton boll worm, Helicoverpa armigera. Insect Biochemistry and Molecular Biology. 28:259-264.
　　22. Zhao Xiaofan, Wang Jinxing, Noriko Yagi., Yamamoto Yoshimi, Watabe Shoji, Takahashi Y. Sussum, 1996，Occurrence of a cathepsin B-like acid cystein proteinase in the eggs of silkworm moth, Antheraea pernyi. Comparative Biochemistry and Physiology. 113B: 95-103.
　　21. Takahashi S.Y., Yamamoto Y., Zhao X-F, Watabe S., 1996, Bombyx acid cysteine proteinase. Invertebrate Reproduction and Development. 30:265-281.
　　20. Yamamoto Y., Zhao X-F，Suzuki A.C., Takahashi. S Y., 1994, Cysteine proteinase from the eggs of the Silkworm, Bombyx mori: site of synthesis and a suggested role in yolk protein degradation. Journal of Insect Physiology. 40: 447-454.
　　19. Takahashi S.Y.， Zhao X-F， Kageyama T., Yamamoto Y., 1992，Acid cysteine proteinase from the eggs of silkmoth, Bombyx mori: tissue distribution, developmental changes and the sites of synthesis for the enzyme. Insect Biochemistry and Molecular Biology. 22: 369-377.
　　18. 趙小凡，2007，昆蟲(chóng)蛻皮的分子機(jī)理及應(yīng)用。昆蟲(chóng)知識(shí)，44：323-326。
　　17. 鄭薇薇, 張玉寶, 王金星, 趙小凡*，2007，棉鈴蟲(chóng)蛻皮時(shí)期同工酶表達(dá)模式。昆蟲(chóng)學(xué)報(bào)， 50：317-322。
　　16．董杜鵑 扈進(jìn)冬 張新昌 李子勁 王金星 趙小凡* 2006, HCB在Pichia中的表達(dá)及鑒定。生物工程雜志， 26 : 44-48。
　　15．趙小凡，基因組時(shí)代的昆蟲(chóng)學(xué)。2005，3：26-27。
　　14. 張新昌，劉楊，王金星，趙小凡*, 2005，從大豆中純化棉鈴蟲(chóng)組織蛋白酶B抑制因子HCB-SoyI。昆蟲(chóng)學(xué)報(bào)， 48：849-853。
　　13．楊曉梅，侯立靜，董杜鵑，王金星，趙小凡*，2005, 組織蛋白酶B在棉鈴蟲(chóng)發(fā)育過(guò)程中的表達(dá)及活性研究。山東大學(xué)學(xué)報(bào). 40：119-124。
　　12．邵紅蓮，趙小凡*，董杜鵑，扈進(jìn)冬，邵丁丁，楊曉梅，王金星，2005，棉鈴蟲(chóng)組織蛋白酶B在桿狀病毒表達(dá)系統(tǒng)中的表達(dá)。山東大學(xué)學(xué)報(bào)， 40：107-111。
　　11、楊曉梅，侯立靜，康翠潔，邵紅蓮，張新昌，杜欣軍，王金星，趙小凡*, 2004，棉鈴蟲(chóng)組織蛋白酶B單克隆抗體的制備及鑒定。山東大學(xué)學(xué)報(bào)，39：116-120。
　　10．安曉萌，杜欣軍，邵紅蓮，邵丁丁，趙小凡*，王金星，2004, 棉鈴蟲(chóng)組織蛋白酶B多克隆抗體制備及鑒定。昆蟲(chóng)知識(shí)， 41:132-126。
　　9．杜欣軍，邵丁丁，趙小凡*，王金星，2004, 棉鈴蟲(chóng)組織蛋白酶B在大腸桿菌中的表達(dá)。農(nóng)業(yè)生物技術(shù)學(xué)報(bào)， 12：162-166。
　　8．趙小凡*，蔣曉娟，杜欣軍，徐筠娉，王金星，2004，棉鈴蟲(chóng)蛻皮調(diào)節(jié)轉(zhuǎn)錄因子在大腸桿菌中的重組表達(dá)及包涵體純化。昆蟲(chóng)學(xué)報(bào), 47：281-286。
　　7. 李照民，趙小凡*，王金星，李斐雪，王家寶，王勝利, 2003，非甾醇類(lèi)蛻皮激素競(jìng)爭(zhēng)物RH-2485對(duì)棉鈴蟲(chóng)蛋白質(zhì)組成和表皮結(jié)構(gòu)的影響。動(dòng)物學(xué)研究, 24：140-143。
　　6. 張志宏, 趙小凡*, 王金星, 2002，棉鈴蟲(chóng)卵內(nèi)半胱氨酸蛋白酶的分離純化、氨基酸序列分析及蛋白酶鑒定。昆蟲(chóng)學(xué)報(bào)，45：840-843。
　　5. 張志宏, 王金星, 趙小凡*, 王來(lái)元，2002， 棉鈴蟲(chóng)雌性成蟲(chóng)脂肪體cDNA文庫(kù)的構(gòu)建。山東大學(xué)學(xué)報(bào)， 37：449-451。
　　4. 李照民，趙小凡*, 李斐雪，王金星，2002，RH-2485對(duì)棉鈴蟲(chóng)實(shí)驗(yàn)室防治效果實(shí)驗(yàn)。植物保護(hù)學(xué)報(bào)， 29：78-82。
　　3. 徐夏蓮，趙小凡*, 王金星，2001，棉鈴蟲(chóng)組織蛋白酶B組織分布與合成部位研究。動(dòng)物學(xué)研究，22：242-245。
　　2. 李斐雪, 李照民, 張志宏, 徐夏蓮, 趙小凡*, 王金星, 2001，棉鈴蟲(chóng)半胱氨酸蛋白酶底物特異性研究。農(nóng)業(yè)生物技術(shù)學(xué)報(bào)，9：152-155。
　　1. 趙小凡, 2001, 昆蟲(chóng)學(xué)研究熱點(diǎn)述評(píng)?！秶?guó)際學(xué)術(shù)動(dòng)態(tài)》，2：51-53。

　　*如果發(fā)現(xiàn)導(dǎo)師信息存在錯(cuò)誤或者偏差，歡迎隨時(shí)與我們聯(lián)系，以便進(jìn)行更新完善。

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