山東大學(xué)生命科學(xué)學(xué)院導(dǎo)師：劉祖國(guó) 正文

　　劉相國(guó) 教授
　　博士生導(dǎo)師
　　電話(huà):0531-88364330
　　E-mail:xgliu@sdu.edu.cn
　　 
　　教育背景
　　中國(guó)科學(xué)院微生物研究所 理學(xué)博士學(xué)位（微生物學(xué)），2000
　　山東大學(xué)生命科學(xué)學(xué)院 理學(xué)碩士學(xué)位（細(xì)胞生物學(xué)），1997
　　山東大學(xué)生物系 理學(xué)學(xué)士學(xué)位（生物學(xué)），1994
　　 
　　工作經(jīng)歷
　　2008.8-現(xiàn)在, 細(xì)胞生物學(xué)教授,博士生導(dǎo)師,學(xué)術(shù)帶頭人(第二層次),山東大學(xué)生命科學(xué)學(xué)院
　　2003.9-2008.8, postdoctoral fellow，Department of Hematology/Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA , USA
　　2002.11-2003.8, postdoctoral associate，Department of Molecular Genetics and Microbiology ,College of Medicine, University of Florida, Gainesville, FL, USA.
　　2000.9-2002.11,博士后,北京大學(xué)醫(yī)學(xué)部基礎(chǔ)醫(yī)學(xué)院免疫系。
　　
　　研究方向
　　腫瘤細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)和抗腫瘤藥物篩選:
　　本研究組將以中國(guó)人高發(fā)腫瘤為研究對(duì)象，充分利用分子生物學(xué)，基因組學(xué)及蛋白質(zhì)組學(xué)等技術(shù)，研究腫瘤細(xì)胞發(fā)生、發(fā)展和轉(zhuǎn)移的分子機(jī)理；腫瘤細(xì)胞死亡的分子機(jī)制及信號(hào)轉(zhuǎn)導(dǎo)；抗腫瘤藥物的作用機(jī)制及抗腫瘤靶向藥物篩選系統(tǒng)的構(gòu)建等。
　　
　　研究成果及發(fā)表論文
　　近年發(fā)表論文
　　1.Lin YD*，Liu X*, Yue P, Khuri FR, Sun SY. Involvement of c-FLIP and survivin downregulation in Flex-Het-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells. Molecular Cancer Ther. 2008. 7(11): 3556-3565. (*indicating authors of equal contribution).
　　2.Liu X, Yue P, Chen S, Hu L, Lonial S, Khuri FR, Sun SY. The Proteasome Inhibitor PS-341 (Bortezomib) Up-Regulates DR5 Expression Leading to Induction of Apoptosis and Enhancement of TRAIL-Induced Apoptosis Despite Up-Regulation of c-FLIP and Survivin Expression in Human NSCLC Cells. Cancer Res. 2007 May 15;67 (10):4981-8.
　　3.Liu X, Yue P, Schonthal AH, Khuri FR, Sun SY. Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. Cancer Res. 2006 Dec 1; 66(23):11115-9.
　　4.Liu X, Yue P, Khuri FR, Sun SY. Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity. Cancer Res. 2005. Oct 15; 65(20): 9169-75.
　　5.Liu X, Yue P, Zhou Z, Khuri FR, Sun SY. Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 2004 Dec 1; 96(23): 1769-80.
　　6.Liu X, Yue P, Khuri FR, Sun SY. p53 upregulates death receptor 4 expression through an intronic p53 binding site. Cancer Res. 2004 Aug 1; 64(15): 5078-83.
　　7.Jin F*, Liu X*, Zhou Z, Yue P, Lotan R, Khuri FR, Chung LW, Sun SY. Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Cancer Res. 2005 Jul 15; 65(14):6354-63. (*indicating authors of equal contribution)
　　8.Sun SY, Liu X, Zou W, Yue P, Marcus AI, Khuri FR. The farnesyltransferase inhibitor Lonafarnib induce CHOP-dependent expression of death receptor 5 leading to induction of apoptosis in human cancer cells. J Biol Chem. 2007 Jun 29; 282(26):18800-9. Epub 2007 May 9.
　　9.Qiu Y, Liu X, Zou W, Yue P, Lonial S, Khuri FR, Sun SY. The Farnesyltransferase Inhibitor R115777 Up-regulates the Expression of Death Receptor 5 and Enhances TRAIL-Induced Apoptosis in Human Lung Cancer Cells. Cancer Res. 2007 May 15; 67(10):4973-80.
　　10.Zou W, Liu X, Yue P, Zhou Z, Sporn MB, Lotan R, Khuri FR, Sun SY. c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl- 2-cyano– 3 ,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells. Cancer Res. 2004 Oct 15; 64(20): 7570-8.
　　11.Chang LJ, Liu X, He J. Lentiviral siRNAs targeting multiple highly conserved RNA sequences of human immunodeficiency virus type 1.Gene Ther. 2005 Jul; 12(14):1133-44.
　　12.Chen S, Liu X, Yue P, Schonthal AH, Khuri FR, Sun SY. CHOP-dependent DR5 induction and ubiquitin/proteasome-mediated c-FLIP downregulation contribute to enhancement of TRAIL-induced apoptosis by dimethyl- celecoxib in human non-small cell lung cancer cells. Mol Pharmacol. 2007 Nov;72(5):1269-79. Epub 2007 Aug 7.
　　13.Zou W, Liu X, Yue P, Khuri FR, Sun SY. PPARgamma Ligands Enhance TRAIL-induced Apoptosis through DR5 Upregulation and c-FLIP Downregulation in Human Lung Cancer Cells. Cancer Biol Ther. 2007 Jan 29;6(1);6(1):99-106.
　　14.Zou W, Chen S, Liu X, Yue P, Sporn MB., Khuri FR. and Sun SY. c-FLIP Downregulation Contributes to Apoptosis Induction by the Novel Synthetic Triterpenoid Methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO- Me) in Human Lung Cancer Cells. Cancer Biol Ther. 2007 Oct; 6(10).
　　15.Zhang XY, Liu XG, Wang W, Wang WC, Gao XM. Anti-T-cell humoral and cellular responses in healthy BALB/c mice following immunization with ovalbumin or ovalbumin-specific T cells. Immunology. 2003; 108 (4): 465 – 473.
　　16.Zhao WP, Liu XG, Wang W, Gao XM. Large quantity of ribosomal RNA exists extracellularly in mouse spleen. Histochem J. 2002, Aug-Sep; 34(8-9): 391-6.
　　17.Yang G, Qiu B, Liu X, Li Y, Wang X. Nonsense mutations of replicase and movement protein genes contribute to the attenuation of an avirulent tomato mosaic virus. Virus Res. 2002; 87 (2): 119-128.
　　18.Liu XG, Wang W, Lu Y, Gao XM. T cell vaccination induces regulatory humoral immune response in BALB/c mice. Chin J Immunol. (中國(guó)免疫學(xué)雜志). 2002, 18(9): 604-607.
　　19.Liu XG, Yang G, Qiu BS, Tien P. Construction of fusion gene of HBV (adr) surface antigen determinant and B subunit of Cholera toxin and high level expression in E.coli. Acta Microbiologica Sinica.（微生物學(xué)報(bào)）, 2001, 41(5): 625- 629.
　　20.Liu XG,Yang G, Qiu BS, Tien P. Expression of two truncated enhancin gene from Helicoverpa armigera granulosis virus in E.coli. and its preliminary bioassay, Acta Microbiologica Sinica.（微生物學(xué)報(bào)）. 2001, 41(2): 167-172.
　　21.Liu XG, Yang G, Qiu BS, Tien P. Removing unspecific antibodies with sephacryl gel coupling E.coli. proteins by periodate oxidation. Microbiologica. （微生物學(xué)通報(bào)）. 2001, 28(3):73-75.
　　22.Liu XG, Yang G, Qiu BS, Tien P. Molecular cloning of enhancin gene from Helicoverpa armigera granulosis virus and its expression in E.coli. Acta Microbiologica Sinica.（微生物學(xué)報(bào)）.2000, 40(4):379-383.
　　23.Yang G, Liu XG, Qiu BS. Complete nucleotide sequences and structure analysis of the infectious cDNAs of tobacco mosaic virus (Chinese isolate, vulgar strain) and its attenuated vaccine-N14 (tomato strain) genomes. Chin. J. Biotech.（生物工程學(xué)報(bào)）。.2000. 16(4):437-442.
　　24.Yang G, Liu XG, Qiu BS, Recombinants construction and infectivity analysis of tobacco mosaic virus and attenuated tomato mosaic virus N14 genomes. Chinese sciences bulletin.（科學(xué)通報(bào)）. 2000, 45(15):1399- 1404.
　　25.Zhao WP Liu XG, Wang W, Lv P Zhang L, Gao XM. Relationship Between RNA Released from Mouse Apoptotic Murine Splenocytes and Autoimmune Disease. Chinese Journal of Biochemistry and Molecular Biology.（中國(guó)生物化學(xué)和分子生物學(xué)雜志） 2003,19(5): 662-666.
　　26.Zhang XY, Han SH, Liu XG, Gao XM, et al. T cell vaccination induces regulatory T cell response in BALB/c mice. Chin J Microbiol Immunol.（中華微生物學(xué)免疫學(xué)雜志） 2002, 22(2):127-130.
　　27.Li B, Han SH, Liu XG, Gao XM.T cell vaccination against systemic lupus erythematosus in BXSB mice. Acad J Sec Mil Med Univ. （第二軍醫(yī)大學(xué)學(xué)報(bào)）2002, 23(10): 1091-1096.

　　綜述性文章
　　1.Liu X, Sun SY. FLICE Inhibitory protein. In: Encyclopedia of Cancer (Second Edition). 2008.1131-1133. Springer Berlin Heidelberg. ISBN：978-3-540-36847-2 (Print) 978-3-540-47648-1 (Online)
　　DOI：10.1007/978-3-540-47648-1-2208.

　　*如果發(fā)現(xiàn)導(dǎo)師信息存在錯(cuò)誤或者偏差，歡迎隨時(shí)與我們聯(lián)系，以便進(jìn)行更新完善。

添加山東大學(xué)學(xué)姐微信，或微信搜索公眾號(hào)“考研派小站”，關(guān)注[考研派小站]微信公眾號(hào)，在考研派小站微信號(hào)輸入[山東大學(xué)考研分?jǐn)?shù)線(xiàn)、山東大學(xué)報(bào)錄比、山東大學(xué)考研群、山東大學(xué)學(xué)姐微信、山東大學(xué)考研真題、山東大學(xué)專(zhuān)業(yè)目錄、山東大學(xué)排名、山東大學(xué)保研、山東大學(xué)公眾號(hào)、山東大學(xué)研究生招生）]即可在手機(jī)上查看相對(duì)應(yīng)山東大學(xué)考研信息或資源。

山東大學(xué)