山東大學生命科學學院導師：杜良成 正文

　　杜良成 教授
　　博士生導師
　　電話：0531-88362350
　　Email：ldu3@unl.edu

　　教育及工作背景：
　　學士(BS) 1982.09-1986.07 云南大學生物系, Biology
　　碩士(MS) 1986.09-1989.07 中國科學院昆明植物研究所, Biochemistry
　　博士(PhD) 1993.09-1997.01 Demark, Royal Veterinary and Agricultural University , Biochemistry
　　助理研究員：1989.09-1993.06在中國科學院昆明植物所工作期間主要從事植物抗真菌蛋白的研究；
　　訪問學者：1993.06-09在瑞士Frederick Miescher研究所訪問期間從事水稻細胞懸浮培養(yǎng)物對微生物病原體激發(fā)子的生化反應研究；
　　博士生：1993.09-1997.01博士期間主要從事次生代謝物質(zhì)芥子油苷的生物合成及其代謝工程；
　　博士后：1997.01-2001.07年在美國加州大學DAVIS分校，主要從事抗腫瘤藥物博來霉素的生物合成與代謝工程；
　　助理教授：2001.07-2007.07在美國University of Nebraska-Lincoln，
　　副教授 (tenured)：2007.08至今在美國University of Nebraska-Lincoln, 主要從事腐馬素等病源真菌聚酮化合物，內(nèi)生真菌和新型生防細菌中抗生素及天然藥物的生物合成與代謝工程研究。
　　訪問學者：2009.04-05在美國加州Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla。

　　學術兼職：
　　學術刊物編委：
　　Mycology, an International Journal of Fungal Biology編輯；Acta Botanica Yunnanica編輯.
　　基金評審人：
　　NIH; NSF; NSF China; USDA NRICGP; PRF-AC/G; American Heart Associate; National Sea Grant College Program; Health Research Board, Ireland; Canada Foundation for Innovation.
　　學術刊物審稿人：
　　PNAS; JACS; Biochemistry; AEM; JOC; JAFC; JNP; ChemBioChem; Fungal Gen Biol; Bioorg Chem; Mol Plant-Microbe Interact; FEMS Microbiol Ecol; Mycologia; Progress in Natural Sciences; ACS Book Chapter.
　　國際學術會議組織者：
　　Organizer and Co-chair of “Fungal Polyketides — Biosynthesis, Pathogenesis, and Regulation”, Society for Industrial Microbiology, July 29-August 2, 2007;
　　Chair of Session “Biologically-related Molecules and Process”, 234th American Chemical Society National Meeting, August 19-23, 2007.

　　學術會員:
　　1998至今，美國化學學會會員Member of American Chemical Society
　　2002至今，美國科學促進會會員Member of American Association for the Advancement of Science
　　2004至今，美國微生物學學會會員Member of American Society of Microbiology

　　研究方向：
　　真菌聚酮的生物合成機理
　　新穎抗真菌天然產(chǎn)物的遺傳學和功能

　　科研項目：
　　2011.01-2012.12 31028019 產(chǎn)酶溶桿菌的抗水稻病原菌活性成分分離和生物合成研究 國家自然科學基金海外及港澳學者合作研究基金
　　2010.01-2012.12 30970244 番茄對鏈格孢菌侵染和AAL-Toxin的抗性的激素互作調(diào)控機制 國家自然科學基金
　　2010.01-2010.12 Biosynthetic Mechanism for Plant Cyclopeptides Nebraska Research Council
　　2009.07-2011.05 NIH Stimulus ARRA NIH, Stimulus fund
　　2009.05-2011.05 #59-0206-9-087 Control of DON Production in Grain with Non-Toxigenic Strains of Fusarium USDA-ARS
　　2009.01-2011.12 P2008-KF02 太子參環(huán)肽B的生物合成研究 State Key Lab grant, # P2008-KF02
　　2008.06-2011.05 AI073510-02 Biosynthesis of HSAF, a broad spectrum antifungal natural product with a novel mode of action NIH, AI073510-02
　　2006.09-2009.08 #0614916 Biosynthesis of mycotoxin fumonisins: characterization of enzymes for vicinal diol and tricarballylic ester formation NSF-MCB #0614916
　　2005.01-2007.12 #30428023 玉米中真菌毒素腐馬素的生物合成及其安全性控制 NSFC Oversea Young Scholar Award
　　2004.07-2008.06 Functional and chemical characterization of a novel broad spectrum antimycotic from Lysobacter enzymogenes Nebraska Research Initiatives

　　發(fā)表論文：
　　Lou L, Chen H, Cerny RL, Li Y, Shen Y, and Du L. 2012. Unusual Activities of the Thioesterase Domain for the Biosynthesis of the Polycyclic Tetramate Macrolactam HSAF in Lysobacter enzymogenes C3. Biochemistry 51, 4-6. (Highlighted on Biochemistry website, January 10, 2012)
　　Zhang W, Li Y, Qian G, Wang Y, Chen H, Li Y-Z, Liu F, Shen Y, and Du L. 2011. Identification and Characterization of the Anti-Methicillin-Resistant Staphylococcus aureus WAP-8294A2 Biosynthetic Gene Cluster from Lysobacter enzymogenes OH11. Antimicrobial Agents and Chemotherapy 55, 5581-5589.
　　Xie Y, Zhang W, Li Y, Wang M, Cerny RL, Shen Y, and Du L. 2011. Transformation of Fusarium verticillioides with a polyketide gene cluster isolated from a fungal endophyte activates the biosynthesis of fusaric acid. Mycology 2: 24-29.
　　Lou L, Qian G, Xie Y, Hang J, Chen H, Zaleta-Rivera K, Li Y, Shen Y, Dussault PH, Liu F and Du L. 2011. Biosynthesis of HSAF, a tetramic acid-containing macrolactam from Lysobacter enzymogenes. J Am Chem Soc 133: 643-645.
　　Huffman J, Gerber R, and Du L.Recent advancements in the biosynthetic mechanisms for polyketide-derived mycotoxins.Biopolymers 93,764-776.
　　Du L, Lou L.PKSs and NRPSs releasing mechanisms. Natural Product Reports 27: 255-278.
　　Li Y, Shen Y , Zhu X, and Du L.Introduction of the AAL-toxin polyketide synthase gene ALT1 into FUM1-disrupted Fusarium verticillioides produces metabolites with the fumonisin methylation pattern.J Nat Prod 72: 1328-1330
　　Gerber R, Lou L, and Du L.A PLP-dependent polyketide chain releasing mechanism in the biosynthesis of mycotoxin fumonisins in Fusarium verticillioides.J Am Chem Soc 131:3148-3149
　　Zhu X, Vogeler C, and Du L.Functional complementation of fumonisin biosynthesis in FUM1-disrupted Fusarium verticillioides by the AAL-toxin polyketide synthase gene ALT1 from Alternaria alternata f. sp. Lycopersici.
　　Zu X, Yu F, Li X-C, and Du L.Production of dihydroisocoumarins in Fusarium verticillioides by swapping the ketosynthase domain of the fungal iterative modular polyketide synthase Fum1p with that of lovastatin diketide synthase.J Am Chem Soc 129: 36-37.
　　Yu F, Zaleta-Rivera K, Zhu X, Huffman J, Millet J, Harris SD, Yuen G, Li X, and Du L.Structure and biosynthesis of HSAF, a broad spectrum antimycotic with a novel mode of action.Antimicrob. Agents Chemother. 51: 64-72.
　　Zaleta-Rivera K, Xu C, Yu F, Butchko RAE, Proctor RH, Lara MEH, Raza A, Dussault PH, and Du L.FUM14 encodes a bi-domain nonribosomal peptide synthetase catalyzing the formation of tricarballylic esters in the biosynthesis of fumonisins.Biochemistry 45: 2561-2569.
　　Li S, Du L, Yuen G, and Harris SD.Distinct ceramide synthases regulate polarized growth in the filamentous fungus Aspergillus nidulans.Mol Biol Cell 17: 1218-1227
　　Yu F, Zhu X, and Du L.Developing a genetic system for functional manipulations of FUM1, a polyketide synthase gene for the biosynthesis of fumonisins in Fusarium verticillioides.FEMS Microbiol Lett 248: 257-264.

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