山東大學(xué)公共衛(wèi)生學(xué)院導(dǎo)師:王志玉

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山東大學(xué)公共衛(wèi)生學(xué)院導(dǎo)師:王志玉

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山東大學(xué)公共衛(wèi)生學(xué)院導(dǎo)師:王志玉 正文


  姓 名 王志玉
  性 別 男
  職 稱 教授(博士生導(dǎo)師)
  職 務(wù) 公共衛(wèi)生學(xué)院衛(wèi)生檢驗(yàn)重點(diǎn)實(shí)驗(yàn)室主任
  電 話 88382625
  電子郵件 zhiyu.wang@sdu.edu.cn
  通信地址 濟(jì)南市文化西路44號(hào)(250012)
  最高學(xué)位 博士
  
  學(xué)術(shù)簡(jiǎn)歷 1983 畢業(yè)于山東醫(yī)學(xué)院獲學(xué)士學(xué)位,1986 年畢業(yè)于山東醫(yī)科大學(xué)獲碩士學(xué)位,1993,9~1994,7美國(guó)麻省大學(xué)醫(yī)學(xué)中心分子遺傳學(xué)與微生物學(xué)系WHO高級(jí)訪問學(xué)者,1996,9~1998,9美國(guó)麻省大學(xué)醫(yī)學(xué)中心分子遺傳學(xué)與微生物學(xué)系博士后研究, 2003年畢業(yè)于山東大學(xué)獲博士學(xué)位。
  
  研究方向 醫(yī)學(xué)分子病毒學(xué);病毒學(xué)檢驗(yàn)
  
  社會(huì)兼職
  中華預(yù)防醫(yī)學(xué)會(huì)衛(wèi)生檢驗(yàn)學(xué)分會(huì)委員會(huì)副主任委員;全國(guó)高等學(xué)校衛(wèi)生檢驗(yàn)專業(yè)衛(wèi)生部規(guī)劃教材編寫委員會(huì)委員;國(guó)家食品藥品監(jiān)督管理局保健食品審評(píng)專家;中華醫(yī)學(xué)會(huì)醫(yī)學(xué)病毒學(xué)分會(huì)委員會(huì)常務(wù)委員;山東省學(xué)校衛(wèi)生協(xié)會(huì)副會(huì)長(zhǎng);山東預(yù)防醫(yī)學(xué)會(huì)常務(wù)理事;山東微生物學(xué)會(huì)常務(wù)理事;山東省生物技術(shù)學(xué)會(huì)理事;山東省預(yù)防接種異常反應(yīng)診斷小組成員;山東省艾滋病檢測(cè)實(shí)驗(yàn)室評(píng)審專家組專家;山東省全球基金艾滋病項(xiàng)目專家組成員;《預(yù)防醫(yī)學(xué)論壇》雜志副主編;《中國(guó)衛(wèi)生檢驗(yàn)雜志》常務(wù)編委;《病毒學(xué)報(bào)》編委;《國(guó)際病毒學(xué)雜志》編委;《中國(guó)病毒病雜志》編委等。
  
  目前承擔(dān)的主要研究課題:
  1.國(guó)家自然科學(xué)基金項(xiàng)目:副粘病毒HN蛋白功能性氨基酸定位與促細(xì)胞融合機(jī)制研究.
  2.山東省科技攻關(guān)項(xiàng)目.風(fēng)疹病毒基因工程亞單位疫苗的研究.
  
  主要學(xué)術(shù)論文 :
  1.Zhao-Guo Wang,a,b Ying Yi,a Ting-Ting Yang,a Xiao-Lin Liu,a Fa-Chun Jiang,a Zhi-Yu Wang,b Ji-MingChenEmergency surveillance of influenza during 2009 in the Chinese city of Qingdao. Influenza and Other Respiratory Viruses 5(2011)53~59
  2.Bing Wu, Xiaoli Liu, Zhiyu Wang. Effects of E2 and E1 Glycosylation on Specific Membrane Fusion in Rubella Virus Strain JR23. Intervirology, 2009, 52:68-77
  3.Liu Xl, Wu B, Zhang Wq, Song Yy, Xu Hz, Wang Gt, Wang Zy. Effects Of Disulfide Bridges In Glycoprotein E1 On Fusogenic Activity Of Rubella Virus. Acta Virologica, 2009, 53(1): 29-34
  4.Wenqiang Zhang, Guijie Ren, Bing Wu, Xiaoli Liu, Guiting Wang, Yanyan Song, Hongzhi Xu, Hongling Wen, Zhiyu Wang. Amino Acid Substitutions in Leucine Zipper Motif in the F-Specific Domain of Human Parainfluenza Virus 3 HN Protein Play Important Roles in the Protein Function. Intervirology, 2008, 51(5); 311-321
  5.Guijie Ren, Zhiyu Wang, Xiaoyan Hu. Effects of Ectodomain Sequences between HR1 and HR2 of F1 Protein on the Specific Membrane Fusion in Paramyxoviruses. Intervirology,2007, 50:115-122
  6.Zexin Tao and Zhiyu Wang. Sequence Analysis Of M Genome Segments Of Two Seoul Hantavirus Strains In Shandong, China. Acta Virologica, 2007, 51:67-68
  7.Zexin Tao, Zhiyu Wang, Shaoxia Song, Hongling Wen, Guijie Ren, Guiting Wang. Genetic properties of medium (M) and small (S) genomic RNA segments of Seoul hantavirus isolated from Rattus norvegicus and antigenicity analysis of recombinant nucleocapsid protein. Virus Genes, 2007,34: 23-30
  8.Guijie Ren, Zhiyu Wang, Guiting Wang, Yanyan Song, Ping Yao, Hongzhi Xu, Hongling Wen, Wenqiang Zhang. Effects of Heptad Repeat Regions of F Protein on the Specific Membrane Fusion in Paramyxoviruses. Intervirology, 2006, 49:299-306
  9.Hongling Wen and Zhiyu Wang. Expression and characterization of rubella virus glycoprotein E1 in yeast cells. Intervirology, 2005, 48(5):321-328
  10.Zhiyu Wang, Anne M. Mirza, Jianrong Li, Paul J. Mahon and Ronald M. Iorio. An oligosaccharide at the C-terminus of the F-specific domain in the stalk of the human parainfluenza virus 3 hemagglutinin-neuraminidase modulates fusion. Virus Research, 2004, 99(2):177-185
  11.Zhiyu Wang, Ping Yao, Yanyan Song, Guiting Wang, Yongkang Wang, Hongzhi Xu and Peng Wang. Characteristics and Mechanisms of Isolated Rubella Virus, Strain JR23: Infection of the Central Nervous System of BALB/c Mice. Intervirology, 2003, 46(2): 79-85
  12.Zhiyu Wang and Ronald M. Iorio. Amino acid substitutions in a conserved region in the stalk of the Newcastle disease virus HN glycoprotein spike impair its neuraminidase activity in the globular domain. J Gen Virol,1999,80:749-75
  13.Ruitang Deng, Zhiyu Wang, Paul J. Mahon, Mark Marinello, Anne Mirza, and Ronald M. Iorio. Mutations in the Newcastle disease virus hemagglutinin-neuraminidase protein that interfere with its ability to interact with the homologous F protein in the promotion of fusion. Virology,1999,253:43-54
  14.Ruitang Deng, Zhiyu Wang, Anne A. Mirza, and Ronald M. Iorio. Localization of a Domain on the Paramyxovirus Attachment Protein Required for the Promotion of Cellular Fusion by its Homologous Fusion Protein Spike. Virology,1995,209(2):457-469
  15.Ruitang Deng, Zhiyu Wang, Rhona L. Glickman, and Ronald M. Iorio. Glycosylation within an Antigenic Site on the HN Glycoprotein of Newcastle Disease Virus Interferes with its Role in the Promotion of Membrane Fusion. Virology,1994,204(1):17-26
  16.WANG Zhiyu, XUE Yonglei, WANG Xiaofan, SONG Yanyan, WEN Hongling. Cloning and Sequence Analysis of Envelope Glycoprotein E1 Gene of Rubella Virus, JR23 Strain. Journal of Microbiology and Immunology, 2003, 1(1): 11-16
  
  代表性著作(章節(jié)):
  《醫(yī)學(xué)病毒學(xué)原理》,主編,中國(guó)醫(yī)藥科技出版社,1996
  《病毒學(xué)檢驗(yàn)》主編,人民衛(wèi)生出版社,2006
  
  重要獎(jiǎng)項(xiàng):
  1.風(fēng)疹病毒JR23株包膜糖蛋白的基因克隆與表達(dá)和功能分析,2006年獲山東省科技進(jìn)步獎(jiǎng),二等獎(jiǎng)
  2.副粘病毒融合蛋白誘導(dǎo)細(xì)胞融合的分子機(jī)制,2010年獲山東省科技進(jìn)步獎(jiǎng),三等獎(jiǎng)
  3.中樞神經(jīng)系統(tǒng)風(fēng)疹病毒感染的發(fā)生機(jī)理與防治對(duì)策的研究,2003年獲山東省科技進(jìn)步獎(jiǎng),三等獎(jiǎng)

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