中國海洋大學(xué)海洋生命學(xué)院導(dǎo)師：劉振輝 正文

　　劉振輝，男，博士，教授，碩士生導(dǎo)師。教育部新世紀優(yōu)秀人才?，F(xiàn)任生物系副主任。1971年生。
　　聯(lián)系方式：0532-82032092; zhenhuiliu@ouc.edu.cn
　　
　　研究方向: 海洋生物功能基因研究；脂味覺的分子機制研究；肥胖模型的建立與調(diào)控研究；免疫機制與分子進化研究。

　　研究經(jīng)歷：2012-2013, 美國Utah State University博士后，從事味覺與肥胖調(diào)控機理研究；2007－2008，法國歐洲味覺研究中心博士后，德國漢堡大學(xué)分子神經(jīng)研究所博士后，從事味覺的分子機理研究；2003—現(xiàn)在，中國海洋大學(xué)海洋生命學(xué)院講師、副教授、教授，主要從事原索動物和魚類的發(fā)育、免疫與進化研究。山東省“泰山學(xué)者”研究團隊主力成員；2000－2003, 中國海洋大學(xué)海洋生物學(xué)專業(yè)，獲博士學(xué)位；1997-2000，中國海洋大學(xué)水產(chǎn)養(yǎng)殖專業(yè)，獲碩士學(xué)位。

　　研究課題：海洋“863”重點項目“海洋模式生物文昌魚免疫防御的關(guān)鍵基因研究” （2008AA092603），132萬元，2008－2012；教育部新世紀優(yōu)秀人才項目“魚類卵黃脂磷蛋白免疫新功能的分子機理研究”，50萬元，2009－2011；留學(xué)回國啟動基金，3萬元，2010-2012；國家自然科學(xué)基金 “文昌魚CD19類蛋白的鑒定及基因克隆與進化研究”（30500256），22萬元，2006.1-2008.12；海洋“863” 子課題 “海洋重要動物免疫相關(guān)基因的研究與開發(fā)”（2005AA626012），109萬元， 2005-2006。

　　獎勵：山東省自然科學(xué)獎一等獎一項（第二位），2007年；教育部自然科學(xué)獎二等獎一項（第二位），2006年；國家海洋局海洋創(chuàng)新成果一等獎一項（第五位），2004年；山東省高等學(xué)校自然科學(xué)獎一等獎（第二位），2006年；青島市自然科學(xué)一等獎（第二位），2005年；中國海洋大學(xué)優(yōu)秀班主任和中國海洋大學(xué)“天泰”優(yōu)秀教師獎，2006年。

　　論文：已發(fā)表論文50余篇，其中在SCI源期刊上發(fā)表論文近40篇:
　　1. Yanling Sun, Zhenhui Liu*, Shicui Zhang. Tissue distribution, developmental expression and up-regulation of p8 transcripts on stress in zebrafish. Fish & Shellfish Immunology, 2010, 28:549-554. (通訊作者) IF: 3.1;
　　2. Claire Fenech, Lila Patrikainen, Daniel S. Kerr, Sylvie Grall, Zhenhui Liu, Fabienne Laugerette, Bettina Malnic and Jean-Pierre Montmayeur. Ric-8A, a Gα protein guanine nucleotide exchange factor potentiates taste receptor signaling. Frontiers in Cellular Neuroscience, October 2009 | Volume 3 | Article 11 | 1. doi: 10.3389/neuro.03.011.2009. SCI.
　　3. Zhenhui Liu*, Yanping Xu, Ling Wu and Shicui Zhang. Evolution of galanin receptor genes: insights from the deuterostome genomes. Journal of Biomolecular Structure and Dynamics. 2010,28:1, 97-106. IF：5.0.
　　4. Zhenhui Liu*, Lei Li, Hongyan Li, Shicui Zhang, Guangdong Ji, Yanling Sun. EST analysis of the immune-relevant genes in Chinese amphioxus challenged with lipopolysaccharide. Fish & Shellfish Immunology 26 (2009) 843–849. IF: 3.1;
　　5. Zhenhui Liu*, Yanling Sun, Naiguo Liu, Ningning Fan, Shicui Zhang. Characterization, expression, and response to stress of p8 gene in amphioxus. Fish & Shellfish Immunology. 27 (2009) 407–413. IF: 3.1;
　　6. Jing LUAN, Zhenhui LIU, Shicui ZHANG, Hongyan LI, Chunxin FAN, Lei LI. Characterization, Evolution and Expression of the Calmodulin1 Genes from the Amphioxus Branchiostoma belcheri tsingtauense. Acta Biochimica et Biophysica Sinica. 2007, 39 (4), 255–264. (通訊作者)。IF: 1.0;
　　7. Zhenhui Liu, Shicui Zhang, Hongyan Li, Jing Luan, Yongjun Wang, Lei Wang and Jianhan Xiang. Characterization and expression profile of AmphiCD63 encoding a novel member of TM4SF proteins from amphioxus Branchiostoma belcheri tsingtauense. DNA Sequence.2005， 16(3):195-201. IF: 0.6;
　　8. Zhenhui Liu, Shicui Zhang, Mei Liu, Yongjun Wang, and Anlong Xu, Evolution and expression of the amphioxus AmphiHMGB gene encoding a HMG-box protein. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. 2004, 137:131-138. IF: 1.6;
　　9. Zhenhui Liu, Shicui Zhang, Mei Liu and Anlong Xu. Identification of the Ribosomal Protein S15a and L19 from the Amphioxus Branchiostoma belcheri tsingtauense. OPHELIA. 2004, 58(1): 23-27. IF: 0.9;
　　10. Zhenhui Liu, Jie Kong, Xiaowen Sun and Jingyao Deng. Application of RAPD technique for identification in three different stocks of Penaeus chinensis. Acta Oceanologica Sinica. 2003, 22(4): 629-634. IF: 0.4;
　　11. Zhenhui Liu, Zhang S., Yuan J., Sawant M.S., Wei J., and Xu A. Molecular Cloning and Phylogenetic Analysis of AmphiUbf80, a New Member of Ubiquitin Family from the Amphioxus Branchiostoma belcheri tsingtauense. Current Science 2002, 83, 50-53. IF: 0.6;
　　12. N Liu, S Zhang, Z. Liu. Characterization and expression of gamma-interferon-inducible lysosomal thiol reductase (GILT) gene in amphioxus Branchiostoma belcheri with implications for GILT in innate immune response. Mol Immunol. 2007 Apr;44(10):2631-7. IF 3.7.
　　13. C Fan, S Zhang, Z. Liu. Identification and expression of a novel class of glutathione-S-transferase from amphioxus Branchiostoma belcheri with implications to the origin of vertebrate liver. Int J Biochem Cell Biol. 2007;39(2):450-61. IF 4.0.
　　14. L Wang, S Zhang, Z. Liu. Characterization and expression of amphioxus ApoD gene encoding an archetype of vertebrate ApoD proteins. Cell Biol Int. 2007 Jan;31(1):74-81. IF 1.2.
　　15. Jinduo Yuan, Shicui Zhang, Zhenhui Liu, Zhidong Luan, and Gengxi Hu. Cloning and phylogenetic analysis of an amphioxus myogenic bHLH gene AmphiMDF. Biochemical and Biophysical Research Communications, 2003, 301: 960-967. IF 3.0.
　　16. M. Liu, S. Zhang, Z. Liu, and A. Xu. Characterization, organization and expression of AmphiLysC, an acidic c-type lysozyme gene in amphioxus Branchiostoma belcheri tsingtauense. Gene, 2006, 367: 110-117. IF 2.7.
　　17. He Y, Tang B, Zhang S, Liu Z, Zhao B, Chen L. Molecular and immunochemical demonstration of a novel member of Bf/C2 homolog in amphioxus Branchiostoma belcheri: implications for involvement of hepatic cecum in acute phase response.Fish Shellfish Immunol. 2008 Jun;24(6):768-78. IF 3.2.
　　18. Tian J, Zhang S, Liu Z, Zhuang Y, Wang Y, Jiang S. Characterization and tissue-specific expression of phosphatidylcholine transfer protein gene from amphioxus Branchiostoma belcheri.Cell Tissue Res. 2007 Oct;330(1):53-61. IF 2.6.
　　19. Zhao B, Zhang S, Wang Y, Liu Z, Kong D. Characterization and expression of p23 gene in the amphioxus Branchiostoma belcheri.Comp Biochem Physiol B Biochem Mol Biol. 2006 Sep;145(1):10-5. IF 1.6.
　　20. Wang Y，Zhang S，Liu Z. Characterization and Expression of AmphiCL Encoding Cathepsin L Proteinase from Amphioxus Branchiostoma belcheri tsingtauense. Marine Biotechnology 2005,7: 279-286. IF 1.5.
　　21. Li Z, Zhang S, Zhang J, Liu M, Liu Z. Vitellogenin is a cidal factor capable of killing bacteria via interaction with lipopolysaccharide and lipoteichoic acid. Mol Immunol. 2009 Oct;46(16):3232-9.
　　22. Li L, Zhang S, Fan C, Liu Z, Luan J. Verification and tissue-specific expression of nifU-like gene from the amphioxus Branchiostoma belcheri. DNA Seq. 2008 Feb;19(1):20-7.
　　23. Luan J, Zhang S, Liu Z, Fan C, Ji G, Li L. Characterization, evolution and tissue-specific expression of AmphiCalbin, a novel gene encoding EF-hand calcium-binding protein in amphioxus Branchiostoma belcheri. Acta Biochim Biophys Sin (Shanghai). 2007 Nov;39(11):891-900.
　　24. Tian J, Zhang S, Liu Z, Wang Y. Evolution and expression of gamma-aminobutyric acid type A receptor-associated protein from the amphioxus Branchiostomabelcheri. DNA Seq. 2008 Jun;19(3):319-25.
　　25. Wang Y, Zhang S, Liu Z, Li H, Wang L. Identification and expression of amphioxus beta-microseminoprotein (MSP)-like gene encoding an ancient and rapidly evolving protein in chordates. Comp Biochem Physiol B Biochem Mol Biol. 2005 Nov;142(3):251-7.
　　26. Liu L, Zhang S, Liu Z, Li H, Liu M, Wang Y, Ma L. Ribosomal proteins L34 and S29 of amphioxus Branchiostoma belcheri tsingtauense: cDNAs cloning and gene copy number. Acta Biochim Pol. 2005;52(4):857-62.
　　27. Wang Y, Zhang S, Liu Z, Li H, Wang L. Amphioxus allantoicase: molecular cloning, expression and enzymatic activity. Comp Biochem Physiol B Biochem Mol Biol. 2005 Jun;141(2):237-43.
　　28. Liu NG, Zhang SC, Liu ZH, Liang YJ, Xue JY. Identification and tissue-specific expression of amphioxus GM2 activator protein gene from amphioxus Branchiostoma belcheri. DNA Seq. 2006 Apr;17(2):122-8.
　　29. Xue JY, Zhang SC, Liu NG, Liu ZH. Verification, characterization and tissue-specific expression of UreG, a urease accessory protein gene, from the amphioxus Branchiostoma belcheri. Acta Biochim Biophys Sin (Shanghai). 2006 Aug;38(8):549-55.

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