北京生命科學研究所研究生導師介紹：王曉東
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特別推薦：
王曉東博士，資深研究員，所長，
美國國家科學院院士
XiaodongWang,Ph.D.,Investigator,
DirectoroftheNationalInstituteofBiologicalSciences,Beijing.
HeisamemberoftheNationalAcademyofSciences,USA
電話（Tel）：010-80726688-8501
傳真（Fax）：010-80726689
E-mail：wangxiaodong@nibs.ac.cn
教育經(jīng)歷Education
1984年北京師范大學生物系學士
1991年美國德克薩斯大學西南醫(yī)學中心生物化學博士
工作經(jīng)歷ProfessionalExperience
2004年4月獲美國科學院分子生物學獎，并當選美國國家科學院院士
2003年任北京生命科學研究所所長
2002-present霍華德-休斯醫(yī)學研究所研究員
2001-present美國德克薩斯大學西南醫(yī)學中心生物醫(yī)學科學杰出首席教授
1999-2001美國德克薩斯大學西南醫(yī)學中心生物化學系副教授）
1997-2002霍華德-休斯醫(yī)學研究所助理研究員
1996-1999美國德克薩斯大學西南醫(yī)學中心生物化學系助理教授
1995-1996Emory大學醫(yī)學院生物化學系助理教授，從事哺乳動物細胞凋亡的生物化學途徑的研究
近期論文
1NarimonHonarpour,ChunyingDu,,JamesA.Richardson,RobertE.Hammer,XiaodongWang,andJoachimHerz(2000).AdultApaf-1deficientmiceexhibitmaleinfertility.Dev.Biol.218,248-258.
2.PiotrWidlak,PengLi,XiaodongWang,andWilliamT.Garrard(2000).CleavagepreferencesoftheapoptoticendonucleaseDFF40(caspase-activatedDNaseornuclease)onnakedDNAandchromatinsubstrates.J.Biol.Chem.275,8226-8232.
3.KangLi,YuchengLi,JohnM.Shelton,JamesA.Richardson,ErikaSpencer,ZhijianJ.Chen,XiaodongWang,andR.SandersWilliams(2000).Cytochromecdeficiencycausesembryoniclethalityandattenuatesstress-inducedapoptosis.Cell101,389–399.
4.DavideGenini,ImawatiBudihardjo,WilliamPlunkett,XiaodongWang,CarlosJ.Carrera,HowardB.Cottam,DennisA.Carson,andLorenzoM.Leoni.(2000).NucleotideRequirementsfortheinVitroActivationoftheApoptosisProtein-activatingFactor-1-mediatedCaspasePathway.J.Biol.Chem.275,29-34.
5.Dori,A.Thomas,Chunyingdu,MingXu,XiaodongWang,andTimothyJ.Ley(2000).DFF45/ICADcanbedirectlyprocessedbyGranzymeBduirngtheinductionofapoptosis.Immunity12,621-632.
6.ChunyingDu,MinFang,YuchengLi,LilyLi,andXiaodongWang(2000).Smac,amitochondrialproteinthatpromotescytochromec-dependentcaspaseactivationbyeliminatingIAPinhibition.Cell102,33-42.
王曉東博士，資深研究員，所長，
美國國家科學院院士
XiaodongWang,Ph.D.,Investigator,
DirectoroftheNationalInstituteofBiologicalSciences,Beijing.
HeisamemberoftheNationalAcademyofSciences,USA
電話（Tel）：010-80726688-8501
傳真（Fax）：010-80726689
E-mail：wangxiaodong@nibs.ac.cn
教育經(jīng)歷Education
1984年北京師范大學生物系學士
1991年美國德克薩斯大學西南醫(yī)學中心生物化學博士
工作經(jīng)歷ProfessionalExperience
2004年4月獲美國科學院分子生物學獎，并當選美國國家科學院院士
2003年任北京生命科學研究所所長
2002-present霍華德-休斯醫(yī)學研究所研究員
2001-present美國德克薩斯大學西南醫(yī)學中心生物醫(yī)學科學杰出首席教授
1999-2001美國德克薩斯大學西南醫(yī)學中心生物化學系副教授）
1997-2002霍華德-休斯醫(yī)學研究所助理研究員
1996-1999美國德克薩斯大學西南醫(yī)學中心生物化學系助理教授
1995-1996Emory大學醫(yī)學院生物化學系助理教授，從事哺乳動物細胞凋亡的生物化學途徑的研究
近期論文
1NarimonHonarpour,ChunyingDu,,JamesA.Richardson,RobertE.Hammer,XiaodongWang,andJoachimHerz(2000).AdultApaf-1deficientmiceexhibitmaleinfertility.Dev.Biol.218,248-258.
2.PiotrWidlak,PengLi,XiaodongWang,andWilliamT.Garrard(2000).CleavagepreferencesoftheapoptoticendonucleaseDFF40(caspase-activatedDNaseornuclease)onnakedDNAandchromatinsubstrates.J.Biol.Chem.275,8226-8232.
3.KangLi,YuchengLi,JohnM.Shelton,JamesA.Richardson,ErikaSpencer,ZhijianJ.Chen,XiaodongWang,andR.SandersWilliams(2000).Cytochromecdeficiencycausesembryoniclethalityandattenuatesstress-inducedapoptosis.Cell101,389–399.
4.DavideGenini,ImawatiBudihardjo,WilliamPlunkett,XiaodongWang,CarlosJ.Carrera,HowardB.Cottam,DennisA.Carson,andLorenzoM.Leoni.(2000).NucleotideRequirementsfortheinVitroActivationoftheApoptosisProtein-activatingFactor-1-mediatedCaspasePathway.J.Biol.Chem.275,29-34.
5.Dori,A.Thomas,Chunyingdu,MingXu,XiaodongWang,andTimothyJ.Ley(2000).DFF45/ICADcanbedirectlyprocessedbyGranzymeBduirngtheinductionofapoptosis.Immunity12,621-632.
6.ChunyingDu,MinFang,YuchengLi,LilyLi,andXiaodongWang(2000).Smac,amitochondrialproteinthatpromotescytochromec-dependentcaspaseactivationbyeliminatingIAPinhibition.Cell102,33-42.
7.MichaelLutter,MinFang,XuLuo,MasahiroNishijima,Xiao-songXie,andXiaodongWang(2000).CardiolipinprovidesspecificityforBidtargetingtomitochondria.NatureCellBiol.2,754-756.
8.JijieChai,ChunyingDu,Jia-WeiWu,SawKyin,XiaodongWang,andYigongShi(2000).StructuralandbiochemicalbasisofapoptoticactivationbySmac/DIABLO.Nature406,855-862.
9.XuejunJiangandXiaodongWang(2000).Cytochromecpromotescaspase-9activationbyinducingnucleotidebindingtoApaf-1.J.Biol.Chem.275,31199-31203.
10.GengWu,JijieChai,TomekaSuber,Jia-WeiWu,ChunyingDu,XiaodongWang,andYigongShi(2000).StructuralbasisofIAPrecognitionbySmac/DIABLO.Nature408,1008-1012.
11.TianningYu,XiaodongWang,CheriePurring-Koch,YenWei,andGeorgeL.McLendon(2001).AMutationalepitopeforproapoptoticcytochromecbindingtotheapoptoticproteaseactivationfactor-1(Apaf-1).J.Biol.Chem.276,13034-13038.
12MarisanMejillano,MasayaYamamoto,AndrewLRozelle,Hui-QiaoSun,XiaodongWang,andHelenLYin(2001).Regulationofapoptosisbyphosphatidylinositol4,5Bisphosphateinhibitionofcaspases,andcaspaseinactivationofphosphatidylinositolphosphate5kinases.J.Biol.Chem.276,1865-1872.
13.LilyY.Li,XuLuo,andXiaodongWang(2001)EndonucleaseG(EndoG)isanapoptoticDNasewhenreleasedfromMitochondria.Nature412,95-99.
14.JayParrish,LilyLi,KristinaKlotz,DuncanLedwich,XiaodongWangandDingXue(2001)TheC.elegansmitochondrialnucleaseEndonucleaseGisimportantforDNAfragmentationandprogressionofapoptosis.Nature412,90-94.
15.NarimonHonarpour,SandraGilbert,BruceLahn,XiaodongWang,andJoachimHerz(2001)Apaf-1deficiencyandneuraltubeclosuredefectsarefoundinfogmice.Proc.Natl.Acad.Sci.USA.98,9683-9687.
16.PiotrWidlak,LilyY.Li,XiaodongWang,andWilliamT.Garrard(2001)ActionofrecombinanthumanapoptoticendonucleaseGonnakedDNAandchromatinsubstrates:CooperationwithexonucleaseandDNaseI.J.Biol.Chem.276,48404-48409.
17.MichaelLutter,GuyPerkins,XiaodongWang(2001).Thepro-apoptoticBcl-2familymembertBidlocalizestomitochondrialcontactsite.BMCCellBiology2,22.
18.JonathanP.Carson,MarcelinaBehnam,JenniferN.Sutton,ChunyingDu,XiaodongWang,DonaldF.Hunt,MichaelJ.Weber,andGeorgeKulik.(2002).SmacIsRequiredforCytochromec-inducedApoptosisinProstateCancerLNCaPCells.CancerRes.62.18-23.
19.DevrimAcehan,XuejunJiang,DavidGeneMorgan,JohnE.Heuser,XiaodongWangandChristopherW.Akey(2002).Three-dimensionalstructureoftheapoptosome:implicationsforassembly,procaspase-9binding,andactivation.Mol.Cell9.423-432.
20.HitoshiOkada,Woong-KyungSuh,JianpingJin,MinnaWoo,ChunyingDu,AndrewElia,GordonS.Duncan,AndrewWakeham,AnnickItie,ScottW.Lowe,XiaodongWang,andTakW.Mak(2002).GenerationandcharacterizationofSmac/DIABLO-deficientmice.Mol.Cell.Biol.22,3509-3517.
21.MohanishDeshmukh,ChunyingDu,XiaodongWang,andEugeneM.Johnson,Jr.(2002).ExogenousSmacinducescompetenceandpermitscaspaseactivationinsympatheticneurons.Italic22,8018-8027.
22.XuejunJiang,Hyun-EuiKim,HongjunShu,YingminZhao,HaichaoZhang,JamesKofron,JenniferDonnelly,DaveBurns,Shi-chungNg,SaulRosenberg,andXiaodongWang(2003).DistinctiverolesofPHAPproteinsandprothymosin-αinadeathRegulatoryPathway.Science299,223-226.
23.DeepakNijhawan,MinFang,ElieTraer,QingZhong,WenhuaGao,FengheDuandXiaodongWang(2003).EliminationofMcl-1isrequiredfortheinitiationofapoptosisfollowingultravioletirradiation.Genes&Dev.17,1475-1486.
24.QinghuaLiu,TimA.Rand,SavithaKalidas,FengheDu,Hyun-EuiKim,DeanP.Smithand(2003).R2D2,abridgebetweentheinitiationandeffectorstepsoftheDrosophilaRNAipathway.Science301,1921-1925.
25.JianhuaZhang,MeiDong,LilyLi,YunxiaFan,PurnimaPathre,JinDong,DanwenLou,JamesM.Wells,DanyvidOlivares-Villagómez,LucVanKaer,XiaodongWang,andMingXu(2003).EndonucleaseGisrequiredforearlyembryogenesisandnormalapoptosisinmice.Proc.Natl.Acad.Sci.USA.100,15782-15787.
26.LinLi,RannyMathewThomas,HidetakaSuzuki,JefK.DeBrabander,XiaodongWang,andPatrickG.Harran(2004).AsmallmoleculeSmacmimicpotentiatesTrail-andTNFa-mediatedcelldeath.ScienceInPress.
8.JijieChai,ChunyingDu,Jia-WeiWu,SawKyin,XiaodongWang,andYigongShi(2000).StructuralandbiochemicalbasisofapoptoticactivationbySmac/DIABLO.Nature406,855-862.
9.XuejunJiangandXiaodongWang(2000).Cytochromecpromotescaspase-9activationbyinducingnucleotidebindingtoApaf-1.J.Biol.Chem.275,31199-31203.
10.GengWu,JijieChai,TomekaSuber,Jia-WeiWu,ChunyingDu,XiaodongWang,andYigongShi(2000).StructuralbasisofIAPrecognitionbySmac/DIABLO.Nature408,1008-1012.
11.TianningYu,XiaodongWang,CheriePurring-Koch,YenWei,andGeorgeL.McLendon(2001).AMutationalepitopeforproapoptoticcytochromecbindingtotheapoptoticproteaseactivationfactor-1(Apaf-1).J.Biol.Chem.276,13034-13038.
12MarisanMejillano,MasayaYamamoto,AndrewLRozelle,Hui-QiaoSun,XiaodongWang,andHelenLYin(2001).Regulationofapoptosisbyphosphatidylinositol4,5Bisphosphateinhibitionofcaspases,andcaspaseinactivationofphosphatidylinositolphosphate5kinases.J.Biol.Chem.276,1865-1872.
13.LilyY.Li,XuLuo,andXiaodongWang(2001)EndonucleaseG(EndoG)isanapoptoticDNasewhenreleasedfromMitochondria.Nature412,95-99.
14.JayParrish,LilyLi,KristinaKlotz,DuncanLedwich,XiaodongWangandDingXue(2001)TheC.elegansmitochondrialnucleaseEndonucleaseGisimportantforDNAfragmentationandprogressionofapoptosis.Nature412,90-94.
15.NarimonHonarpour,SandraGilbert,BruceLahn,XiaodongWang,andJoachimHerz(2001)Apaf-1deficiencyandneuraltubeclosuredefectsarefoundinfogmice.Proc.Natl.Acad.Sci.USA.98,9683-9687.
16.PiotrWidlak,LilyY.Li,XiaodongWang,andWilliamT.Garrard(2001)ActionofrecombinanthumanapoptoticendonucleaseGonnakedDNAandchromatinsubstrates:CooperationwithexonucleaseandDNaseI.J.Biol.Chem.276,48404-48409.
17.MichaelLutter,GuyPerkins,XiaodongWang(2001).Thepro-apoptoticBcl-2familymembertBidlocalizestomitochondrialcontactsite.BMCCellBiology2,22.
18.JonathanP.Carson,MarcelinaBehnam,JenniferN.Sutton,ChunyingDu,XiaodongWang,DonaldF.Hunt,MichaelJ.Weber,andGeorgeKulik.(2002).SmacIsRequiredforCytochromec-inducedApoptosisinProstateCancerLNCaPCells.CancerRes.62.18-23.
19.DevrimAcehan,XuejunJiang,DavidGeneMorgan,JohnE.Heuser,XiaodongWangandChristopherW.Akey(2002).Three-dimensionalstructureoftheapoptosome:implicationsforassembly,procaspase-9binding,andactivation.Mol.Cell9.423-432.
20.HitoshiOkada,Woong-KyungSuh,JianpingJin,MinnaWoo,ChunyingDu,AndrewElia,GordonS.Duncan,AndrewWakeham,AnnickItie,ScottW.Lowe,XiaodongWang,andTakW.Mak(2002).GenerationandcharacterizationofSmac/DIABLO-deficientmice.Mol.Cell.Biol.22,3509-3517.
21.MohanishDeshmukh,ChunyingDu,XiaodongWang,andEugeneM.Johnson,Jr.(2002).ExogenousSmacinducescompetenceandpermitscaspaseactivationinsympatheticneurons.Italic22,8018-8027.
22.XuejunJiang,Hyun-EuiKim,HongjunShu,YingminZhao,HaichaoZhang,JamesKofron,JenniferDonnelly,DaveBurns,Shi-chungNg,SaulRosenberg,andXiaodongWang(2003).DistinctiverolesofPHAPproteinsandprothymosin-αinadeathRegulatoryPathway.Science299,223-226.
23.DeepakNijhawan,MinFang,ElieTraer,QingZhong,WenhuaGao,FengheDuandXiaodongWang(2003).EliminationofMcl-1isrequiredfortheinitiationofapoptosisfollowingultravioletirradiation.Genes&Dev.17,1475-1486.
24.QinghuaLiu,TimA.Rand,SavithaKalidas,FengheDu,Hyun-EuiKim,DeanP.Smithand(2003).R2D2,abridgebetweentheinitiationandeffectorstepsoftheDrosophilaRNAipathway.Science301,1921-1925.
25.JianhuaZhang,MeiDong,LilyLi,YunxiaFan,PurnimaPathre,JinDong,DanwenLou,JamesM.Wells,DanyvidOlivares-Villagómez,LucVanKaer,XiaodongWang,andMingXu(2003).EndonucleaseGisrequiredforearlyembryogenesisandnormalapoptosisinmice.Proc.Natl.Acad.Sci.USA.100,15782-15787.
26.LinLi,RannyMathewThomas,HidetakaSuzuki,JefK.DeBrabander,XiaodongWang,andPatrickG.Harran(2004).AsmallmoleculeSmacmimicpotentiatesTrail-andTNFa-mediatedcelldeath.ScienceInPress.